C KIT SIGNALLING REQUIREMENTS IN TCR LINEAGE COMMITMENT

描述（改编自主要研究者摘要）：总体 本项目的目标是定义以下功能的后果： 蛋白酪氨酸激酶受体c-Kit与其 配体，干细胞因子（SCF）在T淋巴细胞发育过程中。 的 该项目旨在确定功能性细胞间 由c-Kit和SCF介导的通信事件， 器官特异性T淋巴细胞发育的生物学。 具体而言是 研究者提出如下建议：1）确定胸腺的作用， 胸腺细胞和肠T细胞中基质源性干细胞因子 2）确定肠上皮细胞衍生的作用 肠T细胞发育中干细胞因子和3）确定 干细胞因子和白细胞介素7是冗余或协同的细胞因子 胸腺和肠道T细胞的发育。

DESCRIPTION (Adapted from the Principal investigator's Abstract): Overall goal of this project is to define the functional consequences of interactions between the protein tyrosine kinase receptor, c-Kit, and its ligand, stem cell factor (SCF) during development of T lymphocytes. The project aims to define the consequences of functional intercellular communication events mediated by c-Kit and SCF that are significant to the biology of organ-specific T lymphocyte development. Specifically, the investigator proposes as follows: 1) to determine the role of thymic stromal-derived stem cell factor in thymocyte and intestinal T-cell development, 2) to determine the role of intestinal epithelial cell-derived stem cell factor in intestinal T-cell development and 3) to determine if stem cell factor and interleukin 7 are redundant or synergistic cytokines for thymic and intestinal T-cell development.