Innovative growth factor functionalized products for the lifescience research market

适用于生命科学研究市场的创新生长因子功能化产品

• 批准号: 830129
• 金额: $ 62.46万
• 依托单位: CELL GUIDANCE SYSTEMS LIMITED
• 依托单位国家: 英国
• 项目类别: Innovation Loans
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=830129
• 关键词: Innovative; growth; factor; functionalized; products

Proteins control the development and maintenance of human tissues. Using bioengineering techniques, essentially any given protein can be copied and manufactured. These purified recombinant proteins are fundamental to modern biotechnology and have many diagnostic and therapeutic applications. For example, recombinant insulin is used to treat diabetes. Recombinant proteins, especially growth factors, are also widely used in regenerative medicine research. Despite their importance, the potential utility of growth factors is critically impaired by their fragility - they break down quickly before they have achieved a useful effect. By improving stability, their medical and commercial value of can be transformed. For example, multiple injections of ordinary insulin can now be replaced by a single daily injection of stabilized insulin. Although some proteins have been stabilized, effective stabilization for most proteins remains problematic. Cell Guidance Systems has developed PODS, a “plug-and-play” platform technology which can stabilize essentially any given protein. The technology employs the unique properties of a polyhedrin protein which self-assembles into robust crystals to encase and armour the target protein. To date, we have made >95 such stabilized proteins. Here, we plan to incorporate PODS proteins into support materials to create functionalized biomaterials (bioinks, microcarriers and microspheres, and electrospun materials). These will initially be sold to the regenerative medicine research market and may ultimately be developed for therapeutic use.

蛋白质控制着人体组织的发育和维持。利用生物工程技术，基本上任何给定的蛋白质都可以被复制和制造。这些纯化的重组蛋白是现代生物技术的基础，并具有许多诊断和治疗应用。例如，重组胰岛素用于治疗糖尿病。重组蛋白，特别是生长因子，也广泛用于再生医学研究。尽管它们很重要，但它们的脆弱性严重损害了生长因子的潜在效用--它们在达到有用的效果之前就很快分解了。通过提高稳定性，可以转化其医疗和商业价值。例如，普通胰岛素的多次注射现在可以被稳定胰岛素的每日一次注射所取代。虽然一些蛋白质已经被稳定化，但大多数蛋白质的有效稳定仍然是个问题。Cell Guidance Systems开发了PODS，这是一种“即插即用”平台技术，可以稳定基本上任何给定的蛋白质。该技术利用了多角体蛋白的独特性质，该蛋白自组装成坚固的晶体，以包裹和保护目标蛋白质。到目前为止，我们已经制造了超过95种这样的稳定蛋白质。在这里，我们计划将PODS蛋白纳入支持材料中，以创建功能化的生物材料（生物墨水，微载体和微球，以及静电纺丝材料）。这些产品最初将出售给再生医学研究市场，最终可能被开发用于治疗用途。