BIOBEHAVIORAL IRREGULARITY AND CONTROL OF IDDM

说明： 这项拟议的为期三年的研究旨在检查胰岛素依赖型糖尿病 糖尿病(IDDM)是反复出现的功能障碍过程的生成者，可以 以包括失调的生物和 行为因素，血糖(BG)异常，严重低血糖 (SH)和高糖化血红蛋白，以及不规则的生物行为 参数。这项跨学科研究将创建个人评估 协议、先进的数据分析方法和易于阅读的标准化 评价生物和行为异常因素的产出 与IDDM相关。第一阶段将专注于生物和生物的建模 行为因素及其相互作用和对极端血糖的影响 不规范。第2阶段将制定单独的协议，用于评估 失调因素，设计非标准高级数据分析 算法和软件。阶段3将使用数据验证这些协议 来自弗吉尼亚大学正在进行的研究，乔斯林糖尿病 Center和Amylin制药公司。

DESCRIPTION: The proposed three year study intends to examine Insulin Dependent Diabetes Mellitus (IDDM) as a generator of a recurrent dysfunction process that can be characterized by a loop that includes dysregulated biological and behavioral factors, blood glucose (BG) irregularity, severe hypoglycemia (SH) and high glycosylated hemoglobin, and irregular bio-behavioral parameters. This interdisciplinary study will create individual assessment protocols, advanced data analysis methods, and simple to read standardized output for evaluation of biological and behavioral irregularity factors associated with IDDM. Phase 1 will focus on modeling of biologic and behavioral factors, their interaction and contributions to extreme BG irregularity. Phase 2 will create individual protocols for assessment of dysregulated factors, designing non-standard advanced data analysis algorithms and software. Phase 3 will validate these protocols using data from ongoing studies at the University of Virginia, the Joslin Diabetes Center, and Amylin Pharmaceuticals.