STUDY OF CLOSED-LOOP GLUCOSE CONTROL IN PEOPLE WITH TYPE 1 DIABETES
STUDY OF CLOSED-LOOP GLUCOSE CONTROL IN PEOPLE WITH TYPE 1 DIABETES
批准号:
7951494
负责人:
BORIS P KOVATCHEV
金额:
$7.7万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-03-01 至 2010-02-28
关键词:
AccountingAlgorithmsArtificial PancreasClinical ResearchComputer Retrieval of Information on Scientific Projects DatabaseComputer SimulationCoupledDevelopmentDiabetes MellitusFundingGeneric DrugsGrantHeart RateIndividualInstitutionInsulin Infusion SystemsInsulin-Dependent Diabetes MellitusMetabolicOGTTPatientsPersonsPhysical activityReactionResearchResearch PersonnelResourcesSourceSystemTestingUnited States National Institutes of Healthblood glucose regulationglucose metabolismglycemic controlin vivoinsulin sensitivitypilot trialresearch study
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Increasing scientific and industrial effort is focused on the development of closed-loop systems (artificial pancreas) to control glucose metabolism in people with diabetes, particularly T1DM. Experiments are being conducted with CGM coupled with insulin pumps and a control algorithm. While such systems have proven feasible in steady metabolic states, they fail during changing metabolic demands, such as meals and physical activity. In order to account for such metabolic disturbances we have developed and tested in silico a new closed-loop control algorithm, which uses individual parameters of insulin sensitivity and heart rate.
The proposed pilot trial will test this algorithm in vivo with T1DM patients who use insulin pumps to maintain glycemic control. Changes in heart rate will be used as a correlate to increased metabolic demand.
If successful, this study will establish the following paradigm: instead of approaching a person "blindly" with a generic control algorithm, an initial test (e.g. oral glucose tolerance test) would allow setting individual parameters, which then will be used to initialize closed-loop control. This approach has the potential to overcome some of the current limitations of closed-loop control, particularly its inability to account for the highly idiosyncratic reaction of a person to metabolic disturbances, such as meals and physical activity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Network Control of Diabetes: Aligning Artificial Pancreas Design with Physiology
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批准号:8641036
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项目类别:
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资助金额:$344.1万
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财政年份:2013
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负责人:BORIS P KOVATCHEV
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依托单位:
IMPROVING METABOLIC CONTROL AND REDUCING HYPOGLYCEMIC RISK IN TYPE 1 DM
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批准号:8167156
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项目类别:
-
资助金额:$4.41万
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财政年份:2010
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负责人:BORIS P KOVATCHEV
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依托单位:
Bio-Behavioral Feedback and Control of Type 1 Diabetes
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批准号:7996764
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项目类别:
-
资助金额:$0.4万
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财政年份:2010
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负责人:BORIS P KOVATCHEV
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依托单位:
COUNTER-REGULATORY IMPAIRMENT AND MICROVASCULAR INSULIN TRANSFER IN TYPE 1 DM
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批准号:8167160
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项目类别:
-
资助金额:$2.0万
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财政年份:2010
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负责人:BORIS P KOVATCHEV
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依托单位:
MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
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批准号:7938743
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项目类别:
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资助金额:$74.81万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
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批准号:8325919
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项目类别:
-
资助金额:$67.08万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
COUNTER-REGULATORY IMPAIRMENT AND MICROVASCULAR INSULIN TRANSFER IN TYPE 1 DM
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批准号:7951477
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项目类别:
-
资助金额:$4.78万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
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批准号:8137258
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项目类别:
-
资助金额:$74.17万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
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批准号:8535733
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项目类别:
-
资助金额:$63.68万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
Closed-Loop Control Modalities in Type 1 Diabetes: Efficacy and System Acceptance
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批准号:8878487
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项目类别:
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资助金额:$69.9万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
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批准号:7791872
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项目类别:
-
资助金额:$73.07万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
IMPROVING METABOLIC CONTROL AND REDUCING HYPOGLYCEMIC RISK IN TYPE 1 DM
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批准号:7951472
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项目类别:
-
资助金额:$14.53万
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财政年份:2009
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负责人:BORIS P KOVATCHEV
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依托单位:
COUNTER-REGULATORY IMPAIRMENT AND MICROVASCULAR INSULIN TRANSFER IN TYPE 1 DM
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批准号:7718565
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项目类别:
-
资助金额:$8.19万
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财政年份:2008
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负责人:BORIS P KOVATCHEV
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依托单位:
IMPROVING METABOLIC CONTROL AND REDUCING HYPOGLYCEMIC RISK IN TYPE 1 DM
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批准号:7718558
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项目类别:
-
资助金额:$18.53万
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财政年份:2008
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负责人:BORIS P KOVATCHEV
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依托单位:
IMPROVING METABOLIC CONTROL AND REDUCING HYPOGLYCEMIC RISK IN TYPE 1 DM
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批准号:7606705
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项目类别:
-
资助金额:$17.46万
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财政年份:2007
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负责人:BORIS P KOVATCHEV
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依托单位:
COUNTER-REGULATORY IMPAIRMENT AND MICROVASCULAR INSULIN TRANSFER IN TYPE 1 DM
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批准号:7606712
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项目类别:
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资助金额:$9.71万
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财政年份:2007
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负责人:BORIS P KOVATCHEV
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依托单位:
Bio-Behavioral Monitoring and Control of IDDM
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批准号:6757831
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项目类别:
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资助金额:$33.13万
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财政年份:1996
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负责人:BORIS P KOVATCHEV
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依托单位:
Bio-Behavioral Feedback and Control of Type 1 Diabetes
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批准号:7232367
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项目类别:
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资助金额:$48.3万
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财政年份:1996
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负责人:BORIS P KOVATCHEV
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依托单位:
Bio-Behavioral Monitoring and Control of IDDM
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批准号:6603557
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项目类别:
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资助金额:$33.13万
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财政年份:1996
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负责人:BORIS P KOVATCHEV
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依托单位:
BIOBEHAVIORAL IRREGULARITY AND CONTROL OF IDDM
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批准号:2701216
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项目类别:
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资助金额:$6.44万
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财政年份:1996
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负责人:BORIS P KOVATCHEV
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依托单位:
海外基金