FUNCTIONAL MRI OF EMOTIONAL UNDERSTANDING IN AUTISM
自闭症患者情绪理解的功能 MRI
基本信息
- 批准号:2793732
- 负责人:
- 金额:$ 1.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-03-29 至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The proposed research is designed to extend our understanding of the
neuropathology underlying one of the core behavioral characteristics of
autism, deficits in emotional understanding. Autism is a severe and
pervasive developmental disorder characterized by marked impairments in
social relatedness and understanding, an integral component of which is
emotional understanding and responsiveness. Although this has been well
characterized behaviorally, previous empirical research on
neurobiological substrate of these deficits has been limited by the
available methodologies. Recent advances in functional imaging
technology, however, allow for a more direct examination of the neural
systems implicated in processing emotion, systems which are presumably
damaged in individuals with autism. fMRI will be used to measure in
vivo, neural activity while participants watch film clips judged to
depict examples of positive and negative emotions. These measurements
will be obtained from 30 adolescents and adults with high-functioning
autism and 30 matched, non-autistic controls. It is hypothesized that
(1) in the non-autistic sample, emotional stimuli will elicit distinct
patterns of neural activation, involving the limbic association cortex,
and (2) positive, approach-related emotions will elicit activation
distinct from negative, withdrawal-related emotions, involving
hemispheric asymmetries. It is further hypothesized that (3) autistic
participants will exhibit a pattern of neural activation distinct from
non-autistics when presented with emotional stimuli, and (4) that
autistic subjects will have particular difficulty with more complex,
cognitively mediated emotions, such as embarrassment, than non-autistic
subjects. This research is designed to add to our understanding of the
underlying pathophysiology of autism, and to provide a possible
extension to neurological models of the understanding and processing of
emotion in normal development.
这项拟议的研究旨在扩大我们对
神经病理学的核心行为特征之一,
自闭症情感理解缺陷自闭症是一种严重的,
广泛性发育障碍,特征是
社会关系和理解,其中一个组成部分是
情感理解和反应能力。 虽然这已经很好了
以前的实证研究表明,
这些缺陷的神经生物学底物受到限制,
可用的方法。 功能影像学研究进展
然而,技术允许对神经系统进行更直接的检查,
与处理情绪有关的系统,
在自闭症患者中受损。 fMRI将用于测量
当参与者观看电影片段时,
描绘积极和消极情绪的例子。 这些测量
将从30名青少年和成人中获得高功能
自闭症和30个匹配的非自闭症对照组。它是假设
(1)在非自闭症的样本中,情绪刺激会引起明显的
神经激活的模式,包括边缘联合皮层,
(2)积极的、与接近相关的情绪会引起激活
与消极的、与退缩有关的情绪不同,
半球不对称进一步假设(3)自闭症
参与者会表现出一种不同于
非自闭症患者在受到情绪刺激时,以及(4)
孤独症受试者将特别难以处理更复杂的,
认知介导的情绪,如尴尬,比非自闭症
科目 这项研究旨在增加我们对
自闭症的潜在病理生理学,并提供一个可能的
扩展到神经模型的理解和处理
正常发展的情绪。
项目成果
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