DOPAMINE MODULATION OF PPI AND LMA IN KNOCKOUT MICE

敲除小鼠中 PPI 和 LMA 的多巴胺调节

• 批准号: 2642256
• 负责人: REBECCA J RALPH-WILLIAMS
• 金额: $ 1.7万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-11 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2642256
• 关键词: amphetamines; behavioral /social science research tag; chordate locomotion; dopamine agonists; dopamine antagonists; dopamine receptor; dopamine transporter; gene targeting; genetically modified animals; injection /infusion; laboratory mouse; psychomotor function; psychopharmacology; sensorimotor system

DESCRIPTION (adapted from the applicant's abstract): Schizophrenia is one of the most prevalent neuropsychiatric disorders in our country today. By establishing the neural substrates mediating specific deficits of this disorder the development of better treatments might be accomplished. PPI (a measure of sensorimotor gating) is a normal cross-species occurrence that is deficient in schizophrenic patients. This impairment in PPI has been successfully modelled in rats through the use of DA agonists and these deficits have been then reversed using DA antagonists and antipsychotics. The goal of this project is to use recently developed "knockout" mice to investigate the role of DA in the modulation of PPI. Background pharmacology studies will be conducted, as few experiments have been done using mice. The second aim of this proposal is to characterize the D2 receptor knockout and the DAT knockout mice in PPI and locomotor activity sessions and investigate pharmacological manipulations of their behavior. In summary, this proposal seeks to determine the role of DA in the modulation of PPI and locomotor activity through the use of genetically altered mice.

描述（摘自申请人摘要）：精神分裂症是其中之一