DOPAMINE MODULATION OF PPI AND LMA IN KNOCKOUT MICE

敲除小鼠中 PPI 和 LMA 的多巴胺调节

• 批准号: 2890070
• 负责人: REBECCA J RALPH-WILLIAMS
• 金额: $ 2.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-12 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2890070
• 关键词: amphetamines; behavioral /social science research tag; chordate locomotion; dopamine agonists; dopamine antagonists; dopamine receptor; dopamine transporter; gene targeting; genetically modified animals; injection /infusion; laboratory mouse; psychomotor function; psychopharmacology; sensorimotor system

DESCRIPTION (adapted from the applicant's abstract): Schizophrenia is one of the most prevalent neuropsychiatric disorders in our country today. By establishing the neural substrates mediating specific deficits of this disorder the development of better treatments might be accomplished. PPI (a measure of sensorimotor gating) is a normal cross-species occurrence that is deficient in schizophrenic patients. This impairment in PPI has been successfully modelled in rats through the use of DA agonists and these deficits have been then reversed using DA antagonists and antipsychotics. The goal of this project is to use recently developed "knockout" mice to investigate the role of DA in the modulation of PPI. Background pharmacology studies will be conducted, as few experiments have been done using mice. The second aim of this proposal is to characterize the D2 receptor knockout and the DAT knockout mice in PPI and locomotor activity sessions and investigate pharmacological manipulations of their behavior. In summary, this proposal seeks to determine the role of DA in the modulation of PPI and locomotor activity through the use of genetically altered mice.

描述（改编自申请人的摘要）：精神分裂症是一种 最常见的神经精神疾病的一部分 通过 建立神经基质介导这种特异性缺陷， 疾病的发展，更好的治疗方法可能会完成。 生产者价格指数（a） 感觉运动门控的测量）是正常的跨物种发生， 精神分裂症患者的缺陷 PPI的这种减值已经 通过使用DA激动剂在大鼠中成功建模， 然后使用DA拮抗剂和抗精神病药逆转了缺陷。 该项目的目标是使用最近开发的“敲除”小鼠， 研究DA在PPI调节中的作用。 背景 药理学研究将进行，因为很少有实验已经完成 使用老鼠。 本提案的第二个目的是描述D2的特点， 受体敲除和DAT敲除小鼠的PPI和运动活性 会议和调查他们的行为的药理学操纵。 总之，本建议旨在确定发展援助在 通过使用基因调节PPI和自发活动 改变的老鼠