KELOIDS--AN IN VITRO MODEL OF FIBROPROLIFERATIVE DISEASE
瘢痕疙瘩——纤维增生性疾病的体外模型
基本信息
- 批准号:6107047
- 负责人:
- 金额:$ 7.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-08-01 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:biological models cell growth regulation collagen disease /disorder proneness /risk elastin extracellular matrix proteins fibroblasts fibronectins gene expression gene mutation human tissue interleukin 1 keloid skin disorder molecular cloning neoplastic growth phorbols prostaglandins protein biosynthesis radioimmunoassay radionuclides regulatory gene smooth muscle tissue /cell culture transcription factor transforming growth factors
项目摘要
The long term goal of this multidisciplinary project is to identify
abnormal regulatory characteristics of fibroblasts and smooth muscle
cells (SMC) cultured from fibrotic lesions in order to elucidate the
pathogenesis of fibroproliferative disorders, and to use genetic
approaches to identify genes that predispose to these conditions,
particularly in persons of African descent. Characteristics to be
studied in cultured cells are those reported to be abnormally regulated
in fibroproliferative conditions, i.e., keloids and rheumatoid
arthritis. Responses to be examined are cell growth and synthesis of
matrix proteins, specifically, collagen, elastin, and
fibronectin. Effectors to be studied include hydrocortisone,
transforming growth factor beta, interleukin-1, prostaglandins and
phorbol esters. General hypotheses to be tested are: (I) a defect in
a regulatory mechanism that controls growth and matrix synthesis
accounts for the fibroproliferative characteristics of cells from
fibrotic lesions, e.g., keloid fibroblasts, gingival fibroblasts from
chronic periodontitis, atherosclerotic SMC, and uterine fibroma SMC;
and (2) mutations in specific genes predispose to fibroproliferative
disorders in persons of African descent.
Specific aims are:
1. determine whether cells from fibrotic lesions differ from normal
cells in regulation of growth and matrix synthesis by the above
effectors;
2. characterize the mechanisms of these differences by determining the
step(s) on the signal transduction pathway involved in misregulation
and the step on the gene expression pathway at which misregulation
occurs;
3. use position cloning techniques to identify genes responsible for
keloids and hypertension.
这个多学科项目的长期目标是确定
成纤维细胞和平滑肌的异常调节特性
从纤维化病变中培养的细胞(SMC),以阐明
纤维增生性疾病的发病机制,并利用遗传学
识别易患这些疾病的基因的方法,
特别是在非洲人后裔中。应具备的特点
在培养细胞中研究的是据报道被异常调节的那些
在纤维增生性条件下,即瘢痕疙瘩和类风湿
关节炎。要检查的反应是细胞生长和合成
基质蛋白,特别是胶原蛋白、弹性蛋白和
纤维连接蛋白。待研究的效应物包括氢化可的松,
转化生长因子β、白介素1、前列腺素和
佛波醇酯。需要检验的一般假设是:(I)
控制生长和基质合成的调节机制
解释了细胞的纤维增殖特性
纤维性病变,如瘢痕疙瘩成纤维细胞,牙龈成纤维细胞
慢性牙周炎、动脉粥样硬化性SMC和子宫纤维瘤SMC;
以及(2)特定基因突变易导致纤维增生性疾病
非洲人后裔的精神障碍。
具体目标是:
1.确定纤维化病变的细胞是否与正常细胞不同。
上述物质对细胞生长和基质合成的调节作用
效应器;
2.通过确定
S步入调控失调的信号转导通路
以及基因表达途径上的一步,即错误调节
发生;
3.使用位置克隆技术识别负责
瘢痕疙瘩和高血压。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Shirley B. Russell其他文献
Shirley B. Russell的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Shirley B. Russell', 18)}}的其他基金
Gene Expression and Variation in Keloid Fibroblasts
瘢痕疙瘩成纤维细胞的基因表达和变异
- 批准号:
6885066 - 财政年份:2005
- 资助金额:
$ 7.35万 - 项目类别:
Gene Expression and Variation in Keloid Fibroblasts
瘢痕疙瘩成纤维细胞的基因表达和变异
- 批准号:
7008589 - 财政年份:2005
- 资助金额:
$ 7.35万 - 项目类别:
A2: ORAL BIOL FACULTY RECRUIT & DENTAL SCHL INFRASTRUCT IMPROVEMENT: MOLEC BIOL
A2:口腔生物教师招聘
- 批准号:
6505229 - 财政年份:2001
- 资助金额:
$ 7.35万 - 项目类别:
A2: ORAL BIOL FACULTY RECRUIT & DENTAL SCHL INFRASTRUCT IMPROVEMENT: MOLEC BIOL
A2:口腔生物教师招聘
- 批准号:
6205922 - 财政年份:1999
- 资助金额:
$ 7.35万 - 项目类别:
REGULATION OF COLLAGEN EXPRESSION AND CELL GROWTH IN FIBROPROLIFERATIVE DISEASES
纤维增生性疾病中胶原蛋白表达和细胞生长的调节
- 批准号:
6259249 - 财政年份:1999
- 资助金额:
$ 7.35万 - 项目类别:
REGULATION OF COLLAGEN EXPRESSION AND CELL GROWTH IN FIBROPROLIFERATIVE DISEASES
纤维增生性疾病中胶原蛋白表达和细胞生长的调节
- 批准号:
6259226 - 财政年份:1999
- 资助金额:
$ 7.35万 - 项目类别:
REGULATION OF COLLAGEN EXPRESSION AND CELL GROWTH IN FIBROPROLIFERATIVE DISEASES
纤维增生性疾病中胶原蛋白表达和细胞生长的调节
- 批准号:
6259241 - 财政年份:1999
- 资助金额:
$ 7.35万 - 项目类别:
REGULATION OF COLLAGEN EXPRESSION AND CELL GROWTH IN FIBROPROLIFERATIVE DISEASES
纤维增生性疾病中胶原蛋白表达和细胞生长的调节
- 批准号:
6104849 - 财政年份:1998
- 资助金额:
$ 7.35万 - 项目类别:
A2: ORAL BIOL FACULTY RECRUIT & DENTAL SCHL INFRASTRUCT IMPROVEMENT: MOLEC BIOL
A2:口腔生物教师招聘
- 批准号:
6121450 - 财政年份:1998
- 资助金额:
$ 7.35万 - 项目类别:
REGULATION OF COLLAGEN EXPRESSION AND CELL GROWTH IN FIBROPROLIFERATIVE DISEASES
纤维增生性疾病中胶原蛋白表达和细胞生长的调节
- 批准号:
6296300 - 财政年份:1998
- 资助金额:
$ 7.35万 - 项目类别:
相似海外基金
A novel mechanism of cell growth regulation by the intrinsically disordered protein, NPM1
内在无序蛋白 NPM1 调节细胞生长的新机制
- 批准号:
26440021 - 财政年份:2014
- 资助金额:
$ 7.35万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study on the mechanism of cell growth regulation by ST2 and its possible anti-cancerous effect.
ST2调节细胞生长的机制及其可能的抗癌作用研究。
- 批准号:
25460393 - 财政年份:2013
- 资助金额:
$ 7.35万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular Mechanisms for cell growth regulation by Mnk-mediated translational control
Mnk 介导的翻译控制调节细胞生长的分子机制
- 批准号:
24590105 - 财政年份:2012
- 资助金额:
$ 7.35万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Integrating Phosphatidylcholine Metabolism with Cell Growth Regulation
将磷脂酰胆碱代谢与细胞生长调节相结合
- 批准号:
221878 - 财政年份:2010
- 资助金额:
$ 7.35万 - 项目类别:
Operating Grants
UNDERSTANDING THE ROLES OF SMALL GTPASES IN CELL GROWTH REGULATION
了解小 GTP 酶在细胞生长调节中的作用
- 批准号:
7955176 - 财政年份:2009
- 资助金额:
$ 7.35万 - 项目类别:
Roles of the Golgi apparatus in cell growth regulation
高尔基体在细胞生长调节中的作用
- 批准号:
18570173 - 财政年份:2006
- 资助金额:
$ 7.35万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mechanism of cell growth regulation by small G proteins
小G蛋白调节细胞生长的机制
- 批准号:
17014061 - 财政年份:2005
- 资助金额:
$ 7.35万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
The role of Kaiso in cell growth regulation
Kaiso 在细胞生长调节中的作用
- 批准号:
302718-2004 - 财政年份:2004
- 资助金额:
$ 7.35万 - 项目类别:
Postgraduate Scholarships - Master's
Bone Cell Growth Regulation by Runx2/Cbfa1
Runx2/Cbfa1 调节骨细胞生长
- 批准号:
6619987 - 财政年份:2003
- 资助金额:
$ 7.35万 - 项目类别:
Bone Cell Growth Regulation by Runx2/Cbfa1
Runx2/Cbfa1 调节骨细胞生长
- 批准号:
6898940 - 财政年份:2003
- 资助金额:
$ 7.35万 - 项目类别: