MR DETERMINATION OF LUMEN CONTOURS AND PLAQUE COMPONENTS

这项合作计划包括成像、生物力学和血管 生物成分。这一组合提交寻求识别成像， 血流动力学、弹性力学和病理生物学参数 区分易损的动脉粥样硬化斑块。影像 Component将开发和验证磁共振血管成像方法， 颈动脉分叉部的高分辨率三维测量 即将接受动脉内膜切除术。斑块的管腔轮廓和成分 将通过体外磁共振成像和组织学研究进行验证。 目前，识别使任何给定的特定功能 容易破裂的斑块由于缺乏可靠的、 一种可连续监测斑块形态的非侵入性方法 无症状受试者。高分辨率成像与 生物力学和血管提供的病理生理学发现 生物学小组将能够识别斑块的特征 它们定义了脆弱的斑块。有了这些数据，我们就可以 启动一项前瞻性监测计划，以确定有风险的患者。

This collaborative proposal has Imaging, Biomechanics and Vascular Biology components. This combined submission seeks to identify imaging, hemodynamic, elastomechanical and pathobiologic parameters that distinguish the vulnerable atherosclerotic plaque. The Imaging component will develop and validate MR angiographic methods that yield high resolution 3D measurements of the carotid bifurcation in patients about to undergo endarterectomy. Plaque lumenal contour and composition will be validated by ex vivo MR imaging and histologic studies. Currently, identification of the specific features that make any given plaque vulnerable to rupture is hampered by the absence of a reliable, non-invasive method that can serially monitor plaque morphology in asymptomatic subjects. The coupling of high-resolution imaging with the pathophysiologic findings provided by the Biomechanics and Vascular Biology groups will allow identification of the plaque characteristics which define the vulnerable plaque. Armed with this data we could embark on a prospective monitoring program to define patients at risk.