High Framerate Plane-Wave Variance of Acceleration and Vector Flow Imaging for the Characterization of Atherosclerotic Plaque Morphology and Assessment of Vascular Hemodynamics
高帧率平面波加速度方差和矢量流成像用于动脉粥样硬化斑块形态的表征和血管血流动力学的评估
基本信息
- 批准号:10461534
- 负责人:
- 金额:$ 3.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAccelerationAcousticsArterial Fatty StreakBiopsyBlood VesselsBlood flowCalciumCardiacCardiovascular Diagnostic TechniquesCardiovascular DiseasesCarotid ArteriesCarotid EndarterectomyCause of DeathCharacteristicsClinicalCodeCollagenComputer ModelsDataData CollectionDetectionDevelopmentDiagnosticDiagnostic ImagingDisease ProgressionDoppler UltrasoundEnvironmentFutureGeometryGoalsGoldGrowthHeatingHemorrhageHistologicHumanImageImaging DeviceIonizing radiationIschemic StrokeLipidsLiquid substanceLocationMeasurementMeasuresMechanicsMethodsModelingMonitorMorphologic artifactsMorphologyMotionNamesNecrosisNoiseOperative Surgical ProceduresOutcomePatientsPatternPhenotypePhysiciansPhysicsPhysiologic pulsePhysiologicalPlayProceduresPropertyPublic HealthRadiationResolutionRiskRisk AssessmentRuptureSchemeSensitivity and SpecificitySignal TransductionSolidStenosisStressStroke preventionStructureTechniquesTechnologyTimeTissue imagingTissuesTranslatingUltrasonographyValidationWorkatherosclerotic plaque rupturebaseclinical decision-makingcombatcostdesigndiagnosis standardearly screeningelastographyfeature detectionhemodynamicsholistic approachimage processingimaging approachimprovedin vivologarithmmechanical propertiesmeetingsminimally invasivenoveloperationpreclinical studyrisk predictionscreeningshear stresssignal processingsimulationspatiotemporalstroke risktoolultrasoundvector
项目摘要
PROJECT SUMMARY
The need for minimally invasive methods for screening early predictors of ischemic stroke are required to
combat the increase in cardiovascular disease cases while reducing number of unnecessary carotid
endarterectomies, which are invasive but preventative procedures to remove plaques. The current gold-standard
for diagnosis, duplex ultrasound, is often used to detect heavily occluded vasculature, but simply noting the
degree of stenosis is an insufficient measure of plaque rupture vulnerability. Acoustic Radiation Force Impulse
(ARFI) ultrasound technique recently emerged as a potential method to separate vulnerable from stable plaques
through delineation of plaque components. However, as the technique relies on emission of high intensity
focused acoustic pulses, although nondestructive, the potential for tissue heating limits extended uses, while the
long period of data collection increases opportunities for motion artifacts to corrupt data collection and
physiological interpretation of results. The use of a new ultrafast ARFI imaging sequence to evaluate both
plaque structure and surrounding hemodynamics may provide significant advancement in reducing
acquisition time, reducing acoustic heating, and improving risk prediction. There exists overwhelming
evidence that mechanics of plaque growth and rupture are governed by shear forces acting on the vessel walls.
Monitoring the dynamics changes in shear stress in addition to more efficiently detecting plaque composition
may prove a novel avenue for discerning at risk patients with vulnerable atherosclerotic plaques vs those with
stable plaque phenotypes. We propose to further develop and characterize ultrasound parallel transmit
sequences to image tissue in rapid succession and additionally detect multi directional blood flow around the
vasculature. Combining the ARFI elastography, high framerate imaging, and flow information allows a real-time
realizable assessment of the plaque environment throughout the entire cardiac cycle. Therefore, meeting the
aims of the study will further develop diagnostic imaging tools for future stroke risk assessment.
项目摘要
需要采用微创方法筛选缺血性卒中的早期预测因子,
打击心血管疾病病例的增加,同时减少不必要的颈动脉
动脉内膜切除术,这是侵入性的,但预防性的程序,以消除斑块。目前的金本位制
对于诊断,多普勒超声通常用于检测严重闭塞的血管,但只是注意到
狭窄程度不足以衡量斑块破裂的脆弱性。声辐射力脉冲
超声技术最近成为分离易损斑块和稳定斑块的一种潜在方法
通过描绘斑块成分。然而,由于该技术依赖于高强度的发射,
聚焦的声脉冲虽然是非破坏性的,但组织加热的潜力限制了扩展的使用,
长时间的数据收集增加了运动伪影破坏数据收集的机会,
结果的生理学解释。使用一种新的超快ARFI成像序列来评估
斑块结构和周围的血液动力学可以提供显著的进步,
采集时间,减少声加热,并改善风险预测。存在着压倒性的
斑块生长和破裂的机制受作用在血管壁上的剪切力控制的证据。
除了更有效地检测菌斑成分外,还可以监测剪切应力的动态变化
可能证明了一种新的途径,用于区分易受损伤的动脉粥样硬化斑块的风险患者与
稳定的斑块表型。我们建议进一步开发和表征超声并行发射
序列,以快速连续地对组织进行成像,并且另外检测组织周围的多方向血流。
脉管系统结合ARFI弹性成像、高帧率成像和血流信息,
在整个心动周期中对斑块环境进行可实现的评估。因此,会议
这项研究的目的是进一步开发诊断成像工具,用于未来的中风风险评估。
项目成果
期刊论文数量(0)
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Keerthi Surej Anand其他文献
Keerthi Surej Anand的其他文献
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{{ truncateString('Keerthi Surej Anand', 18)}}的其他基金
High Framerate Plane-Wave Variance of Acceleration and Vector Flow Imaging for the Characterization of Atherosclerotic Plaque Morphology and Assessment of Vascular Hemodynamics
高帧率平面波加速度方差和矢量流成像用于动脉粥样硬化斑块形态的表征和血管血流动力学的评估
- 批准号:
10700833 - 财政年份:2022
- 资助金额:
$ 3.92万 - 项目类别:
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