CHILD DISRUPTIVE/MOOD DISORDERS--DIAGNOSIS AND COURSE

描述(改编自申请者摘要)：这是第二阶段 一项三阶段前瞻性纵向研究的250个6- 10岁的捣乱和/或抑郁的男孩。该委员会的总体目标 研究是：扩展儿童破坏性精神病理学的双因素模型 抑郁或情绪化的第三个因素；从外部验证 扩展的三因素模型，使用收敛和发散有效的直接 测量三个因素(即注意力不集中-过度活动，攻击性， 和情绪性)；将扩展的三因素模型与几个 DSM和Achenbach评估模式的各个阶段；增进了解 扰乱性和抑郁性障碍内部和之间的共病； 开发和测试用于组合、评估不同数据的方法 使仪器和告密者做出合理的诊断决定；并作出 以经验为基础的综合提案，将颠覆性和 抑郁障碍/维度。 从绝对的角度来看，被推荐的男孩有八个亚组： (1)独有多动症=H；(2)独有攻击性=A；(3) 完全情绪化=E；(4)过度活跃和攻击性相结合=HA；(5) 过度活跃和情绪化结合=HE；(6)攻击性和情绪化结合 情绪性=AE；(7)多动、攻击性与情绪性混合型=HAE； 以及(8)既不过度活跃也不咄咄逼人，也不情绪化=精神错乱 控制或PC，以及200个同学比较男生或CC，以及80个满分 兄弟们。 外部验证的相关标准包括：症状 表达变量(例如，持续时间、严重程度和普遍性)； 损害变量(学业问题、友谊、治疗)；家庭 背景变量(例如，家庭组成、父母教养方式、婚姻 和谐)；认知和实验室测量(例如，智力功能， 学术技能，CPT)；观察测量(例如，游戏中的行为和 任务设置、父子交互)；代指数(即，子代 和父母的成人维度和障碍)；症状病程 (精神症状/行为维度在平均8岁时评估， 12和15)；以及诊断结果(评估和预测 15岁时的精神障碍/行为维度)。 这一第二阶段的调查将完成250人的后续调查 先证者年龄在11岁到13岁之间；它将包括一个兄弟姐妹 比较组件，使用有关6到10岁儿童和 这些男孩的11到13岁的姐妹和兄弟被转介到 更全面地回答有关表达、诊断和发育的问题 男孩和女孩的破坏性和抑郁维度/障碍。

DESCRIPTION (Adapted from Applicant's Abstract): This is the second phase of a three-phase prospective longitudinal study of 250 6- through 10-year-old disruptive and/or depressive boys. The general aims of the study are: to extend a two-factor model of child disruptive psychopathology to a third factor of depression or emotionality; to externally validate that extended three-factor model, using convergently and divergently valid direct measures of the three factors (i.e., inattention-overactivity, aggression, and emotionality); to compare the extended three-factor model to several stages of the DSM and Achenbach assessment models; to improve understanding of comorbidity within and between the disruptive and depressive disorders; to develop and test methods for combining, assessment data from different instruments and informants into sound diagnostic decisions; and to make a consolidated empirically-derived proposal for subgrouping the disruptive and depressive disorders/dimensions. Considered categorically, there are eight subgroups of referred boys: (1) exclusively hyperactive = H; (2) exclusively aggressive = A; (3) exclusively emotional = E; (4) combined hyperactive and aggressive = HA; (5) combined hyperactive and emotional = HE; (6) combined aggressive and emotional = AE; (7) mixed hyperactive and aggressive and emotional = HAE; and (8) neither hyperactive nor aggressive nor emotional = psychiatric controls or PC, as well as 200 classmate comparison boys or CC, and 80 full brothers. The dependent criteria for external validation include: symptom expression variables (e.g., duration, severity, and pervasiveness); impairment variables (academic problems, friendships, treatments); family context variables (e.g., family composition, parenting styles, marital harmony); cognitive and laboratory measures (e.g., intellectual functioning, academic skills, CPT); observational measures (e.g., behavior in play and task settings, parent-child interactions); generation indices (i.e., child and adult dimensions and disorders in parents); course of symptoms (psychiatric symptoms/behavioral dimensions assessed at average ages of 8, 12, and 15); and diagnostic outcomes (assessment and prediction of psychiatric disorders/ behavioral dimensions at age 15). This second phase of the investigation will complete follow-up of 250 probands between ages 11 and 13; and it will incorporate a sibling comparison component, using information about the 6- through 10-year-old and the 11-through 13-year-old sisters and brothers of the referred boys to answer more fully questions about the expression, diagnosis, and development of disruptive and depressive dimensions/disorders in boys and girls.