THE PREVALENCE AND CLINICAL CHARACTERISTICS OF CYSTIC FIBROSIS ARTHROPATHY

一项前瞻性研究的患病率，发病率，临床 特征、预后特征和病理描述 囊性纤维化关节病（CFA）。CFA的特点是反复发作， 经常是疼痛的单发或多发性关节炎。许多患者也 出现结节性皮疹，或在少数情况下，紫癜 皮肤损伤关节炎的发作持续一天到 好几个星期一些CFA患者进展为慢性关节炎 这会让人很虚弱对CFA的适当处理不是 已知，尚未在大型前瞻性研究中进行研究。研究 正在儿童医院和 马萨诸塞州总医院作为一个联合的努力， 部门和囊性纤维化中心在每个机构。研究 需要通过问卷调查筛选CFA的存在， 随访病历审查、体格检查、实验室检查和 选择性X光片。该研究旨在促进临床和 CFA的基本科学知识，并可能深入了解 可能的预防或治疗措施。

A prospective study of the prevalence, incidence, clinical characteristics, prognostic features, and pathologic description of cystic fibrosis arthropathy (CFA). CFA is characterized by recurrent, often painful bouts of mono-or polyarthritis. Many patients also manifest an erythema-nodosum-like rash, or in a few cases, purpuric skin lesions. The flares of joint inflammation last from one day to several weeks. Some patients with CFA progress to a chronic arthritis that can be quite debilitating. The appropriate treatment of CFA is not known and has not been studied in a large prospective study. The study is being performed simultaneously at Children's Hospital and The Massachusetts General Hospital as a combined effort of the Rheumatology Departments and Cystic Fibrosis Centers at each institution. The study entails screening for the presence of CFA with a questionnaire and follow-up medical chart review, physical exam, laboratory tests and selective radiographs. The study seeks to advance both the clinical and basic scientific knowledge of CFA and possibly gain insight into possible preventive or treatment measures.