RANDOMIZED STUDY OF CLINICAL COHORTING OF CYSTIC FIBROSIS PATIENTS

囊性纤维化患者临床队列的随机研究

• 批准号: 6282054
• 负责人: MICHAEL J ROCK
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282054
• 关键词: Pseudomonas aeruginosa; child (0-11); clinical research; communicable disease transmission; cystic fibrosis; disease /disorder proneness /risk; human subject; nosocomial infections; respiratory disorder epidemiology; respiratory infections

The purpose of this study is to determine risk factors for the acquisition/colonization of respiratory pathogens and particularly Pseudomonas aeruginosa in the respiratory tract of children with cystic fibrosis (CF). The primary hypothesis to be tested is that exposures during clinic visits of young children with CF to older patients who are colonized with Pseudomonas significantly increases the risk of acquisition of this organism in early childhood. This hypothesis will be tested by cohorting clinic visits for infants without Pseudomonas in the Madison CF Center, and comparison will be made to an integrated/ interspersed population of Pseudomonas positive and negative patients in the Milwaukee CF Center. An integrated/interspersed clinic of Pseudomonas positive and negative patients is standard practice in this country. Therefore, the patients in Milwaukee will be receiving the current standard of care.

本研究的目的是确定 呼吸道病原体的获得/定植， 囊性肺患儿呼吸道铜绿假单胞菌感染 纤维化（CF）。 要检验的主要假设是， 在患有CF的年幼儿童到年龄较大的患者的诊所就诊期间， 与假单胞菌定殖显着增加的风险， 在儿童早期获得这种有机体。 这一假设将 通过对没有假单胞菌的婴儿进行队列门诊检查进行测试， 麦迪逊CF中心，并将其与综合/ 假单胞菌阳性和阴性患者的散布群体 在密尔沃基CF中心。 一个综合/分散的诊所， 假单胞菌阳性和阴性的患者是标准的做法，在这方面， 国家 因此，密尔沃基的患者将接受 目前的护理标准。