RANDOMIZED STUDY OF CLINICAL COHORTING OF CYSTIC FIBROSIS PATIENTS

囊性纤维化患者临床队列的随机研究

• 批准号: 6121682
• 负责人: MICHAEL J ROCK
• 金额: $ 3.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121682
• 关键词: Pseudomonas aeruginosa; child (0-11); clinical research; communicable disease transmission; cystic fibrosis; disease /disorder proneness /risk; human subject; nosocomial infections; respiratory disorder epidemiology; respiratory infections

The purpose of this study is to determine risk factors for the acquisition/ colonization of respiratory pathogens and particularly Pseudomonas aeruginosa in the respiratory tract of children with cystic fibrosis (CF). The primary hypothesis to be tested is that exposures during clinic visits of young children with CF to older patients who are colonized with Pseudomonas significantly increases the risk of acquisition of this organism in early childhood. This hypothesis will be tested by cohorting clinic visits for infants without Pseudomonas in the Madison CF Center, and comparison will be made to an integrated/interspersed population of Pseudomonas positive and negative patients in the Milwaukee CF Center. An integrated/interspersed clinic of Pseudomonas positive and negative patients is standard practice in this country. Therefore, the patients in Milwaukee will be receiving the current standard of care.

本研究的目的是确定囊性纤维化 (CF) 儿童呼吸道病原体尤其是铜绿假单胞菌获得/定植的危险因素。 要测试的主要假设是，患有囊性纤维化的幼儿在就诊期间接触到感染假单胞菌的老年患者，会显着增加儿童早期感染这种微生物的风险。 这一假设将通过对麦迪逊 CF 中心没有假单胞菌的婴儿进行队列临床就诊进行检验，并将与密尔沃基 CF 中心的假单胞菌阳性和阴性患者的综合/散布群体进行比较。 假单胞菌阳性和阴性患者的综合/分散诊所是该国的标准做法。 因此，密尔沃基的患者将接受当前标准的护理。