RANDOMIZED STUDY OF CLINICAL COHORTING OF CYSTIC FIBROSIS PATIENTS

本研究的目的是确定囊性纤维化(CF)患儿呼吸道病原体尤其是铜绿假单胞菌感染/定植的危险因素。需要检验的主要假设是，在CF年幼儿童在临床就诊期间接触到居住着假单胞菌的老年患者时，显著增加了儿童早期感染这种微生物的风险。这一假设将通过对麦迪逊CF中心没有假单胞菌的婴儿的临床就诊队列进行检验，并将与密尔沃基CF中心的假单胞菌阳性和阴性患者的综合/散布人群进行比较。在这个国家，假单胞菌阳性和阴性患者的综合/穿插诊所是标准做法。因此，密尔沃基的患者将接受目前的护理标准。

The purpose of this study is to determine risk factors for the acquisition/ colonization of respiratory pathogens and particularly Pseudomonas aeruginosa in the respiratory tract of children with cystic fibrosis (CF). The primary hypothesis to be tested is that exposures during clinic visits of young children with CF to older patients who are colonized with Pseudomonas significantly increases the risk of acquisition of this organism in early childhood. This hypothesis will be tested by cohorting clinic visits for infants without Pseudomonas in the Madison CF Center, and comparison will be made to an integrated/interspersed population of Pseudomonas positive and negative patients in the Milwaukee CF Center. An integrated/interspersed clinic of Pseudomonas positive and negative patients is standard practice in this country. Therefore, the patients in Milwaukee will be receiving the current standard of care.