RANDOMIZED STUDY OF CLINICAL COHORTING OF CYSTIC FIBROSIS PATIENTS

本研究的目的是确定呼吸道病原体，特别是铜绿假单胞菌在囊性纤维化（CF）儿童呼吸道中获得/定植的危险因素。待验证的主要假设是，CF患儿就诊期间与感染假单胞菌的老年患者接触会显著增加幼儿期感染该菌的风险。这一假设将通过麦迪逊CF中心对没有假单胞菌的婴儿的门诊就诊进行验证，并将与密尔沃基CF中心假单胞菌阳性和阴性患者的综合/分散人群进行比较。假单胞菌阳性和阴性患者的综合/分散诊所是该国的标准做法。因此，密尔沃基的病人将接受目前的标准治疗。

The purpose of this study is to determine risk factors for the acquisition/ colonization of respiratory pathogens and particularly Pseudomonas aeruginosa in the respiratory tract of children with cystic fibrosis (CF). The primary hypothesis to be tested is that exposures during clinic visits of young children with CF to older patients who are colonized with Pseudomonas significantly increases the risk of acquisition of this organism in early childhood. This hypothesis will be tested by cohorting clinic visits for infants without Pseudomonas in the Madison CF Center, and comparison will be made to an integrated/interspersed population of Pseudomonas positive and negative patients in the Milwaukee CF Center. An integrated/interspersed clinic of Pseudomonas positive and negative patients is standard practice in this country. Therefore, the patients in Milwaukee will be receiving the current standard of care.