RAPID PORTABLE DETECTION OF DELAYED GASTRIC EMPTYING

胃排空延迟的快速便携式检测

• 批准号: 2868049
• 负责人: HANSEN A MANSY
• 金额: $ 10.49万
• 依托单位: BIOMEDICAL ACOUSTICS RESEARCH COMPANY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2868049
• 关键词: biomedical equipment development; computer assisted diagnosis; diagnosis design /evaluation; gastrointestinal disorder diagnosis; human subject; nuclear medicine; portable biomedical equipment; rapid diagnosis; sound; stomach emptying

The proposed research is to develop an innovative technology for the rapid diagnosis of delayed gastric emptying. The new technology is expected to overcome limitations of the current methods which may include radiation exposure, accuracy, portability, availability and cost. The essential hypothesis is that gastric sounds correlate with gastric motility and emptying patterns. An acoustic sensor (contact microphone) will acquired these sounds while a computer analyzes and reports the presence or absence of changes consistent with a delayed gastric emptying diagnosis. We anticipate that the final product(s) will be both inexpensive and portable. This technology may lead to a substantial decrease in morbidity and health care costs associated with delayed gastric emptying. Phase 1 research will test feasibility in humans by documenting gastric sound patterns in normal subjects and those with delayed gastric emptying. If successful, the novel device would have major commercial potential with possible purchase by hospitals, medical and surgical group practices, plus specialty clinics serving diabetic, eating disorder, and gastroenterology patients. PROPOSED COMMERCIAL APPLICATIONS: This research is aimed at developed a novel diagnostic device with a potential large market. It is anticipated that these products will become standard equipment in hospitals, group medical practices and clinics serving patients with gastrointestinal complaints. The device will be of special use in following those at higher risk of delayed gastric emptying, such as those with diabetes, eating disorders, and renal failure. Preliminary 10 year sales and profit projections are 182 and 34 million dollars, respectively.

拟议的研究是开发一种创新技术，以快速诊断延迟胃排空。预计新技术将克服当前方法的局限性，其中可能包括辐射暴露，准确性，可移植性，可用性和成本。必不可少的假设是胃声与胃运动和排空模式相关。声传感器（接触麦克风）将获得这些声音，而计算机分析并报告存在与延迟胃排空诊断一致的变化。我们预计最终产品将既便宜又便携。这项技术可能导致与胃排空延迟有关的发病率和医疗保健成本大大降低。第1阶段的研究将通过记录正常受试者的胃声模式以及胃排空延迟的胃声模式来测试人类的可行性。如果成功的话，这款新型设备将具有主要的商业潜力，可以通过医院，医疗和外科手术习惯购买，以及为糖尿病，饮食失调和胃肠病学患者提供服务的专业诊所。拟议的商业应用：这项研究旨在开发具有潜在大型市场的新型诊断设备。预计这些产品将成为医院，小组医疗实践和诊所的标准设备，为患有胃肠道投诉的患者提供服务。该设备将特殊用途，以遵循胃排空延迟的风险较高的设备，例如患有糖尿病，饮食失调和肾功能衰竭的设备。初步的10年销售和利润预测分别为182和3400万美元。