ABSORBABLE BRACHYTHERAPY DEVICE FOR CANCER THERAPY

这项提议将导致生物可吸收的近距离放射治疗装置用于局部原发性癌症的治疗和肿瘤切除后的肿瘤床的治疗。这种方法开发了一种全新的近距离治疗方法，使用可吸收的支持基质和螯合放射性核素。生物可吸收的近距离放射治疗材料可以取代传统的永久嵌入的金属源在原发性肿瘤中，并且可能在手术切除局部肿瘤后特别使用。近距离放射治疗材料将提供高度定位的放射治疗，生物可吸收的基质材料消除了对恢复源的后续程序的需要，就像目前所做的那样。在该资助的第ii期，我们将开发放射性标记参数，并在有限的动物研究中评估生物吸收的近距离放射治疗装置的体外和体内，以建立稳定性和安全性。在第二阶段，人类乳腺癌和前列腺癌的动物模型将被用来确定疗效，作为人类试验的前奏。拟议的商业应用：一种生物可吸收的近距离放射治疗装置可用于局部原发性癌症的治疗和肿瘤切除后的肿瘤床的治疗。

This proposal will result in bioabsorbable brachytherapy devices for the treatment of localized primary cancers and treatment of tumor beds after tumor removal. This approach develops an entirely new brachytherapy method using absorbable support matrices and chelated radionuclides. The bioabsorbable brachytherapy materials can replace conventional permanently embedded metal sources in primary tumors, and may be of particular use following surgical removal of localized tumors. The brachytherapy materials will provide highly localized radiation therapy and the bioabsorbable matrix materials eliminate the need for follow-up procedures to recover the sources, as is currently done. In PhaseII of the grant, we will develop radiolabeling parameters and evaluate bioabsorbable brachytherapy devices in vitro and in vivo in limited animal studies to establish stability and safety. In Phase II, animal models of human breast and prostate cancer will be used to establish efficacy as a prelude to testing in humans. PROPOSED COMMERCIAL APPLICATIONS: A biosorbable brachytherapy device can be used for treatment of localized primary cancers and treatment of tumor beds after tumor removal.