FGF-Silyl-Heparin Cerebral Aneurysm Coils

描述（由申请人提供）：脑动脉瘤可能危及生命 由于血管脆弱，它们容易破裂。铂 线圈目前被用作不能手术的脑血管病的实验性治疗， 动脉瘤并通过在动脉瘤内诱导血栓形成而起作用。的 金属/血栓填充动脉瘤，从而恢复更正常的血流 在血管中。目前使用的弹簧圈不会刺激组织向内生长 进入动脉瘤或血管壁，从而离开血管壁 被削弱并具有持续破裂的敏感性。我们建议改善 通过在表面上涂覆改性的专有肝素来进行动脉瘤弹簧圈， 然后利用肝素的亲和力进一步复合碱性成纤维细胞生长 因子（FGF-2）。涂层是简单和成本效益，因为它是执行 使用吸附和亲和技术。FGF将鼓励本地细胞 迁移和增殖导致动脉瘤壁强化 以及用细胞材料填充动脉瘤。我们最初的研究 这表明，肝素可以被修改，以改变释放速率从一个 底物，一个可以帮助控制体内生物利用度的因素。的 I期研究将开发涂层弹簧圈并进行初始动物试验 评价。

DESCRIPTION (provided by applicant): Cerebral aneurysms can be life threatening and because the blood vessel is weak they are subject to rupture. Platinum coils are currently used as an experimental treatment for inoperable cerebral aneurysms and function by inducing thrombosis within the aneurysm. The metal/thrombus fills the aneurysm, thereby restoring a more normal blood flow in the blood vessel. Currently used coils do not stimulate tissue in-growth into the aneurysm or blood vessel wall, thereby leaving the vessel wall weakened and with a continued susceptibility to rupture. We propose improving aneurysm coils by coating a modified, proprietary heparin onto the surface, and then using the affinity of hepann to further complex basic fibroblast growth factor (FGF-2). The coating is simple and cost-effective as it is performed using adsorption and affinity techniques. The FGF will encourage local cell migration and proliferation resulting in a strengthening of the aneurysm wall and a filling of the aneurysm with cellular material. Our initial studies suggest that the heparin can be modified to alter the rate of release from a substrate, a factor that could help control the bioavailability in vivo. The Phase I studies will develop the coated coils and perform initial animal evaluations.