RESTORATIVE MATERIALS BASED ON SILSESQUIOXANE POLYMERS
基于倍半硅氧烷聚合物的修复材料
基本信息
- 批准号:2785077
- 负责人:
- 金额:$ 9.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-05-10 至 2000-02-11
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Current polymeric dental restorative composite precursors have remained largely unchanged for the last 25 years. These materials have several short- comings including (a) the need for large amounts of filler for mechanical strength, (b) incomplete curing, (c) shrinkage, and (d) long term degradation of adhesion. In order to overcome these limitations, advances must be pursued in totally new candidate materials. We propose the use of silsesquioxane hybrid monomers of the formula [(SiO1.5)8(OR)x(OSi[CH3]2R')8-x], where R is a short alkyl chain and R', a polymerizable group such as epoxy rings or ring-bound alkenes. These materials feature the combination of a rigid (SiO1 .5)8 core (imparting strength and stability) with two separate reactive groups: the -OR, which is hydrolytically sensitive and reacts with water molecules bound to the surface of the dentin, and R', for strong bulk polymerization. Other benefits include ease of processability, reduced reliance on inorganic fillers, and increased resistance to an oral environment. Our Phase I objectives to demonstrate the potential of these materials are (1) the synthesis and characterization of relevant silsesquioxane monomers; (2) the determination of their curing behavior; (3) evaluation of their mechanical properties; (4) study the compatibility with nanophase oxides (i.e., TiO2, ZrO2) for cosmetic effects; and (5) preliminary model studies on their durability in oral environments. In Phase II we will further improve the performance of these materials by iterative structure/property studies and proceed with more rigorous studies on their behavior under clinical conditions. PROPOSED COMMERCIAL APPLICATIONS: In addition to the intended function as dental restoratives, these materials could have applications in other medical prosthetics, matrix materials for fiber matrix composites, and advanced adhesives.
目前的聚合物牙科修复复合材料前体在过去 25 年里基本保持不变。这些材料有几个缺点,包括(a)需要大量填料来提高机械强度,(b)固化不完全,(c)收缩,以及(d)粘合力长期下降。为了克服这些限制,必须在全新的候选材料中取得进展。我们建议使用式[(SiO1.5)8(OR)x(OSi[CH3]2R')8-x]的倍半硅氧烷杂化单体,其中R是短烷基链,R'是可聚合基团,例如环氧环或环键烯烃。这些材料的特点是刚性 (SiO1 .5)8 核心(赋予强度和稳定性)与两个独立的反应基团的组合:-OR(对水解敏感并与结合到牙本质表面的水分子发生反应)和 R'(用于强本体聚合)。其他优点包括易于加工、减少对无机填料的依赖以及提高对口腔环境的抵抗力。我们展示这些材料潜力的第一阶段目标是(1)相关倍半硅氧烷单体的合成和表征; (2) 其固化行为的测定; (3) 力学性能评价; (4) 研究与纳米氧化物(即TiO2、ZrO2)的相容性以达到美容效果; (5)其在口腔环境中的耐久性的初步模型研究。在第二阶段,我们将通过迭代结构/性能研究进一步提高这些材料的性能,并对其在临床条件下的行为进行更严格的研究。拟议的商业应用:除了作为牙齿修复剂的预期功能外,这些材料还可应用于其他医疗修复、纤维基质复合材料的基质材料和高级粘合剂。
项目成果
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ANTHONY C SUTORIK其他文献
ANTHONY C SUTORIK的其他文献
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{{ truncateString('ANTHONY C SUTORIK', 18)}}的其他基金
Nanostructured Zirconia Ceramics for Joint Prosthetics
用于关节假体的纳米结构氧化锆陶瓷
- 批准号:
6737043 - 财政年份:2004
- 资助金额:
$ 9.94万 - 项目类别: