THIRD INTERNATIONAL RESEARCH SYMPOSIUM ON CMT DISORDERS

Charcot-Marie-Tooth病(CMT)是最常见的遗传性外周疾病 人类的神经病。自上一届国际会议以来 CMT，由夏科-玛丽-牙齿协会于1988年发起， 我们对CMT的理解有了很大的进步。这个 大多数脱髓鞘形式的CMT的遗传原因是 已确定，包括最常见的CMT形式。这个 周围神经系统(PNS)髓鞘形成的分子生物学， 包括雪旺细胞-轴突的相互作用，已经发展到 许多分子的结构和功能参与了 CMT的发病机制日益明了。病毒的发展 将基因导入PNS的载体，并对其进行鉴定 促进神经再生和髓鞘再生的营养因子，现在 使基因治疗CMT成为未来的现实可能性。 第三届夏科特-玛丽国际研究研讨会的目的- 牙科疾病将通过以下方式促进CMT的进一步研究 一群参与CMT相关的杰出调查人员聚集在一起 为期3天的CMT研讨会的研究，2)会议在 隐居环境，促进调查人员之间的互动，3) 通过以下方式促进参与CMT研究的年轻研究者的成长 邀请他们参加会议，并发布 会议情况介绍，以提供关于国家的最新案文 最先进的CMT研究。

Charcot-Marie-Tooth disease(CMT)is the most common inherited peripheral neuropathy in humans. Since the previous international conference on CMT, sponsored by the Charcot-Marie-Tooth Association in 1988, considerable advances have occurred in our understanding of CMT. The genetic causes of most of the demyelinating forms of CMT have been identified, including that of the most frequent form of CMT. The molecular biology of peripheral nervous system (PNS) myelination, including Schwann cell-axonal interactions, has grown to the point that the structure and function of many of the molecules involved in the pathogenesis of CMT are becoming clear. The development of viral vectors to introduce genes into the PNS, and the identification of trophic factors to promote nerve regeneration and remyelination, are now making gene therapy for CMT a realistic possibility in the future. The purpose of the Third International Research Symposium Charcot-Marie- Tooth Disorders is to promote further research in CMT by 1) Bringing together a group of distinguished investigators involved in CMT related research for a 3 day symposium on CMT, 2) holding the conference in a cloistered setting to promote interaction between investigators, 3) promoting the growth of young investigators involved in CMT research by soliciting their participation in the meeting, and publishing presentations from the meeting to provide an updated text on the state of the art CMT research.