ANGIOTENSIN II AND PROLACTIN RELEASE--ROLE OF ESTROGEN

血管紧张素 II 和催乳素释放——雌激素的作用

• 批准号: 2615236
• 负责人: PHYLLIS CALLAHAN
• 金额: $ 10.5万
• 依托单位: MIAMI UNIVERSITY OXFORD
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2615236
• 关键词: angiotensin II; estrogens; estrus; female; gonadotropin releasing factor; hormone regulation /control mechanism; inositol phosphates; laboratory rat; luteinizing hormone; ovariectomy; pituitary gland; progesterone; prolactin; secretion

DESCRIPTION (Adopted from applicant's abstract): Angiotensin II (AII), an octapeptide that is a component of the renin-angiotensin system, is produced within the anterior pituitary gland of rats and humans, and appears to play a paracrine (rat) or autocrine (human) role in regulation of prolactin secretion. This research proposes to examine the effects of estrogen on rat lactotroph sensitivity to the paracrine mediator AII. Specifically, the hypothesis to be tested is that the pattern and levels of estrogen secretion (or replacement) influences anterior pituitary lactotroph sensitivity to AII-and LHRH-induced stimulation of prolactin secretion. Ovariectomized, prepubertal female rats will be injected with estrogen and progesterone to induce LH surges in a pattern that mimics estrous cyclicity. A second group of ovariectomized animals will receive no steroids, and a third group will not be ovariectomized. Anterior pituitary cells from these animals at six months of age will be exposed to physiological doses of AII and LHRH to determine the prolactin secretory response. Accumulation of inositol phosphates (IP), the second messenger which mediates the AII stimulation of lactotrophs, and AII receptor binding characteristics will also be investigated.

描述（摘自申请人摘要）：血管紧张素II （AII）

项目成果

Effect of steroids and nitric oxide on pituitary hormone release in ovariectomized, peripubertal rats.

类固醇和一氧化氮对卵巢切除围青春期大鼠垂体激素释放的影响。

• DOI: 10.1530/rep.1.00472
• 发表时间: 2005
• 期刊: Reproduction (Cambridge, England)
• 作者: Russell,JillM;Murphree,E;Janik,J;Callahan,P
• 通讯作者: Callahan,P

Effects of cyclic steroid hormone replacement on prolactin and luteinizing hormone surges in female rats.

环状类固醇激素替代对雌性大鼠催乳素和黄体生成素激增的影响。

• DOI: 10.1530/rep.1.00017
• 发表时间: 2004
• 期刊: Reproduction (Cambridge, England)
• 作者: Brown,AM;Janik,JM;Murphree,ES;King,R;Callahan,P
• 通讯作者: Callahan,P