NEUROTROPHIN REGULATION OF CEREBROVASCULAR AXONS

神经营养因子对脑血管轴突的调节

• 批准号: 2636984
• 负责人: LORI G ISAACSON
• 金额: $ 10.5万
• 依托单位: MIAMI UNIVERSITY OXFORD
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2636984
• 关键词: aging; axon; catecholamines; cell growth regulation; cerebrovascular system; immunocytochemistry; laboratory rat; neural plasticity; neuronal guidance; neurotrophic factors; norepinephrine

DESCRIPTION: This is a proposal for an Academic Research Enhancement Award (AREA)-R15. The long-term goal of the proposed studies is to understand the specific mechanisms underlying neural plasticity in the adult. The studies are to be carried out in an in vivo model of sympathetic and sensory perivascular axons associated with extracerebral blood vessels. Responses to intracerebroventricular infusions of nerve growth factor (NGF) are assessed. Attention is focused on sprouting responses and neurotransmitter levels after the NGF infusions. The pilot studies outlined in the application will investigate changes in the regulation of cerebrovascular axons by NGF during the aging process. Experiments will rigorously quantify and relate morphological changes with immunohistochemical observations and biochemical measurements. The proposed experiments would determine age-related change in: 1) the role of neuronal activity in the regulation of cerebrovascular axons; 2 the plasticity of sympathetic cerebrovascular axons; 3) the effects of long-term NGF infusion on cerebrovascular innervation.

描述：这是一个学术研究促进奖的建议 （区域）-R15。 拟议研究的长期目标是了解 成年人神经可塑性的具体机制。 研究 将在交感神经和感觉神经的体内模型中进行 与脑外血管相关的血管周围轴突。 响应 脑室内注射神经生长因子（NGF） 评估。 注意力集中在萌芽反应和神经递质 注射NGF后的水平。 《2000年世界卫生组织 应用将研究脑血管调节的变化， 神经生长因子在衰老过程中对轴突的影响。 实验将严格量化 并将形态学变化与免疫组化观察相关联， 生化测量。 拟议的实验将确定 年龄相关的变化：1）神经元活动的调节作用 交感神经脑血管轴突的可塑性 神经生长因子长期输注对脑血管的影响 神经支配

项目成果

Plasticity of aged perivascular axons following exogenous NGF: analysis of catecholamines.

外源性 NGF 后老化血管周围轴突的可塑性：儿茶酚胺分析。

• DOI: 10.1016/s0197-4580(01)00238-x
• 发表时间: 2002
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Dickason,AK;Isaacson,LG
• 通讯作者: Isaacson,LG

Evidence that nerve growth factor mediates the formation of sensory pericellular baskets in the rat trigeminal ganglion.

有证据表明神经生长因子介导大鼠三叉神经节感觉细胞周篮的形成。

• DOI: 10.1016/s0304-3940(02)00874-1
• 发表时间: 2002
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Shoemaker,SE;Isaacson,LG
• 通讯作者: Isaacson,LG

The effects of deafferentation and exogenous NGF on neurotrophins and neurotrophin receptor mRNA expression in the adult superior cervical ganglion.

传入阻滞和外源性 NGF 对成人颈上神经节神经营养蛋白和神经营养蛋白受体 mRNA 表达的影响。

• DOI: 10.1016/j.molbrainres.2003.08.015
• 发表时间: 2003
• 期刊: Brain research. Molecular brain research
• 作者: DeCouto,SA;Jones,EE;Kudwa,AE;Shoemaker,SE;Shafer,AJ;Brieschke,MA;James,PF;Vaughn,JC;Isaacson,LG
• 通讯作者: Isaacson,LG