PEROXIDES AND ARACHIDONATE METABOLISM IN ANTERIOR UVEA
前葡萄膜中的过氧化物和花生四烯酸代谢
基本信息
- 批准号:2612895
- 负责人:
- 金额:$ 10.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-04-01 至 2001-03-31
- 项目状态:已结题
- 来源:
- 关键词:carbachol eicosanoid metabolism electron microscopy enzyme linked immunosorbent assay eye pharmacology hydrogen peroxide iris laboratory rabbit neural transmission norepinephrine prostaglandin endoperoxide synthase prostaglandins radioimmunoassay sympathetic nervous system toxicant interaction toxin metabolism uvea uvea ciliary body
项目摘要
DESCRIPTION: Although hydrogen peroxide (H2O2) is present in several
tissues of the anterior segment of the eye, its
pharmacological/toxicological functions is yet to be fully determined.
Evidence from the PI's laboratory reveals that H2O2 can potentiate
sympathetic neurotransmission in the iris-ciliary body of several mammalian
species, an effect which is dependent on the age of the animal. The present
project will test the hypothesis that both cyclooxygenase (COX) and non-COX
products of arachidonic acid metabolism mediate some of the
pharmacological/toxicological effects of H2O2 in the anterior uvea. The
overall objective of the present study is to determine the role of
prostanoids and isoprostanes (IsoP's) in the pharmacological/toxicological
effects caused by H2O2 in the anterior uveal tissues both in vitro and in
vivo. Experiments have been designed to answer the following questions?
(a) are prostanoids and IsoP's involved in the pharmacological/toxicological
effects of H2O2 on sympathetic neurotransmission and on postjunctional
responses of anterior uveal tissues to pharmacological agents in vitro? (b)
does exogenously applied H2O2 increase the production of prostanoids and
IsoP's in the iris-ciliary body followed by washout of these compounds into
the aqueous humor? (c) can endogenous concentrations of H2O2 in the
anterior uveal tissues be increased up to a level where it can stimulate the
production of prostanoids and IsoP's? (d) does in vivo biochemical changes
induced by exogenous and endogenous H2O2 correlate with morphological
alterations of anterior uveal tissues by this oxidant? The result of this
study will improve our understanding of the basic mechanisms involved in the
effects of H2O2 on anterior uveal tissues and may reveal a new role for this
oxidant in the pathophysiology/toxicology of the eye. The PI anticipates
that the findings of this project will be applicable to diseases of the
anterior segment of the eye such as glaucoma, uveitis or cataract.
描述:虽然过氧化氢(H2 O2)存在于几种
眼前段的组织,其
药理学/毒理学功能尚未完全确定。
来自PI实验室的证据表明,H2 O2可以增强
几种哺乳动物虹膜睫状体交感神经传递
物种,这是依赖于动物的年龄的影响。 本
该项目将检验环氧化酶(考克斯)和非考克斯
花生四烯酸代谢产物介导了一些
H2 O2在前葡萄膜中的药理学/毒理学作用。 的
本研究的总体目标是确定
前列腺素和异前列腺素(IsoP)在药理学/毒理学
H_2O_2对前葡萄膜组织的影响
vivo. 实验的目的是回答以下问题?
(a)前列腺素类和IsoP参与药理学/毒理学
H2 O2对交感神经传递和连接后神经元的影响
前葡萄膜组织对体外药物的反应? (B)
外源性应用H2 O2是否增加前列腺素类的产生,
虹膜-睫状体中的IsoP,随后将这些化合物洗脱到
眼房水吗 (c)内源性H2 O2浓度在
前葡萄膜组织增加到一个水平,它可以刺激
前列腺素和异前列腺素的产生 (d)体内生物化学变化
外源和内源H_2O_2诱导的形态学变化与
这种氧化剂会改变前葡萄膜组织吗 这样做的结果
研究将提高我们对参与的基本机制的理解,
H2 O2对前葡萄膜组织的影响,并可能揭示这一新的作用
在眼睛的病理生理学/毒理学中的氧化剂。 PI预计
该项目的研究结果将适用于
眼睛的前段,如青光眼、葡萄膜炎或白内障。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes.
异前列烷增强牛离体虹膜交感神经传递。
- DOI:10.1080/10715760100300791
- 发表时间:2001
- 期刊:
- 影响因子:3.3
- 作者:Opere,CA;Awe,SO;Harris,LC;LeDay,AM;Ohia,SE
- 通讯作者:Ohia,SE
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SUNNY EDET OHIA其他文献
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{{ truncateString('SUNNY EDET OHIA', 18)}}的其他基金
HYDROGEN PEROXIDE AND RETINAL NEUROTRANSMITTER RELEASE
过氧化氢和视网膜神经递质释放
- 批准号:
6706849 - 财政年份:2001
- 资助金额:
$ 10.4万 - 项目类别:
HYDROGEN PEROXIDE AND RETINAL NEUROTRANSMITTER RELEASE
过氧化氢和视网膜神经递质释放
- 批准号:
6226897 - 财政年份:2001
- 资助金额:
$ 10.4万 - 项目类别:
OXIDATIVE STRESS AND UVEAL NOREPINEPHRINE RELEASE
氧化应激和葡萄膜去甲肾上腺素释放
- 批准号:
2165260 - 财政年份:1995
- 资助金额:
$ 10.4万 - 项目类别:
OXIDATIVE STRESS AND UVEAL NOREPINEPHRINE RELEASE
氧化应激和葡萄膜去甲肾上腺素释放
- 批准号:
2165261 - 财政年份:1995
- 资助金额:
$ 10.4万 - 项目类别:
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