Dietary effects on renal eicosanoid metabolism

饮食对肾脏类二十烷酸代谢的影响

• 批准号: 217412-2009
• 负责人: Aukema, Harold
• 金额: $ 2.7万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=504197
• 关键词: Dietary; effects; renal; eicosanoid; metabolism

Nutrition is an important determinant of kidney physiology. This proposal seeks to explore how nutrients affect important regulatory compounds called eicosanoids in the kidney. Eicosanoids are biologically active compounds that are made from fatty acids in tissues. These compounds are important in maintaining normal kidney function, especially when the kidneys are damaged. The type and amount of eicosanoids that are made in the kidney is influenced by the types of fatty acids present in the kidney and the activity of the proteins (enzymes) which mediate the formation of these compounds.

营养是肾脏生理的重要决定因素。 该提案旨在探索营养素如何影响肾脏中称为类花生酸的重要调节化合物。 类二十烷酸是由组织中的脂肪酸制成的生物活性化合物。 这些化合物对维持正常的肾功能很重要，特别是当肾脏受损时。 肾脏中产生的类二十烷酸的类型和量受肾脏中存在的脂肪酸类型和介导这些化合物形成的蛋白质（酶）活性的影响。