3D COMPUTER AIDED PROSTATE BIOPSY SYSTEM FOR GUDIANCE

这个SBIR项目的主要目标是开发一种3D计算机- 辅助前列腺活检系统为临床医师提供指导 为个别患者进行真正的临床活组织检查。这个 建议的系统提供了几个有用的功能，包括(L)A 3-D 前列腺的主模型，由一个图形模型组成 主要解剖结构和统计体积显示 前列腺癌的概率图，将被用于选择最优 基于模型的活检指导中的活检部位；(2)此3-D主模型 将覆盖在经直肠超声图像空间上，通过 混合可变形配准程序，使标准协议 和/或计划的活检可以通过基于模型和图像的- 引导方式；(3)系统将以三维方式记录活检结果 以便可以更好地定义后续的回叫再活检，并且 可以推导出更准确的算法来估计肿瘤体积和其他 分段参数。 这种新的方法将改进现有的临床活检实践， 通过在线多通道可视化和变形概率 绘制活组织检查程序图，从而更准确地实现 计划中的活组织检查和更具代表性的癌症样本。 因此，这一创新可以显著提高精度 前列腺癌的诊断和临床分期，从而提高 治疗计划。该系统还将作为培训模块用于 模拟和/或教育目的。 建议的商业应用： 据我们所知，以前还没有在 三维计算机辅助前列腺活检术的开发和商业化 指导、文件编制和培训系统。显然，市场需求 存在的先进产品可以为医生提供更好的指导 和文档在使用优化的 活检点和电子记录，用于后续研究和/或重新检查 活组织检查。这种SBIR将导致3-D计算机辅助前列腺活检 医院用来指导、记录和训练经直肠的系统 超声引导下的前列腺针刺活检。预计将有超过4万人 每年因前列腺癌死亡，拟议研发的影响 对医疗保健的影响是巨大的。

The primary objective of this SBIR project is to develop a 3-D computer- aided prostate biopsy system to provide physician the guidance in performing real clinical biopsy procedures for individual patient. The proposed system provides several useful capabilities, including (l) A 3-D master model of the prostate, consisting of a graphical model showing major anatomical structures and a statistical volume showing the probability maps of prostate cancer, will be used to select optimal biopsy sites in model-based biopsy guidance; (2) This 3-D master model will be overlaid onto transrecrtal ultrasound image space, through a blended deformable registration procedure, so that the standard protocol and/or the planned biopsies can be realized with a model-based and image- guided fashion; (3) The system will record the result of biopsies in 3-D so that the follow-on call-back re-biopsies can be better defined and a more accurate algorithm may be derived to estimate tumor volume and other staging parameters. This novel approach will improve the existing clinical biopsy practice, through on-line multimodal visualization and deformable probability mapping of the biopsy procedure, thus allowing more accurate realization of planned biopsies and more representative samplings of the cancer. Consequently, this innovation could substantially improve the accuracy of prostate cancer diagnosis and clinical staging, thus improving treatment planning. The system will also be used as a training module for simulation and/or education purposes. PROPOSED COMMERCIAL APPLICATIONS: To the best of our knowledge, there has been no previous effort in developing and commercializing a 3-D computer-aided prostate biopsy system for guidance, documentation and training. Clearly, market demand exists for advanced products that can provide physicians better guidance and documentation in performing prostate needle biopsy with optimized biopsy site and electronic record for follow-on studies and/or re- biopsies. This SBIR would lead to a 3-D computer-aided prostate biopsy system for hospital use to guide, document and train transrectal ultrasound-guided prostate needle biopsies. With over 40,000 predicted deaths from prostate cancer every year, the impact of the proposed R&D to healthcare is enormous.