3D Single Fiber Endoscope for Minimally Invasive Surgeries

用于微创手术的 3D 单纤维内窥镜

• 批准号: 8574496
• 负责人: Jason Geng
• 金额: $ 14.81万
• 依托单位: XIGEN, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8574496
• 关键词: Abdomen; Affect; Algorithms; Area; Balloon Angioplasty; Caliber; Cardiology; Client satisfaction; Clinical; Clinical Research; Collaborations; Color; Computational Science; Computer software; Confined Spaces; Data; Decision Making; Development; Devices; Diagnosis; Diagnostic; Economics; Endoscopes; Endoscopy; Engineering; Family suidae; Fiber; Goals; Health system; Hip Joint; Housing; Human; Image; In Vitro; Intervention; Knee; Labyrinth; Lasers; Lead; Light; Location; Lung; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Mechanics; Medical; Methods; Nose; Operative Surgical Procedures; Ophthalmologic Surgical Procedures; Optic Nerve; Optics; Oral cavity; Otolaryngology; Patient Care; Pharmaceutical Preparations; Phase; Positioning Attribute; Postoperative Pain; Procedures; Process; Recording of previous events; Recovery; Rectum; Research; Research Personnel; Resolution; Risk; Scanning; Shoulder; Signal Transduction; Sinus; Site; Skin; Small Business Innovation Research Grant; Solutions; Spottings; Study Section; Surface; Surgical incisions; System; Technology; Testing; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Tooth structure; United States National Institutes of Health; Universities; University Hospitals; Washington; Work; base; cost; design; experience; flexibility; image guided intervention; innovation; instrument; middle ear; minimally invasive; novel; prevent; prototype; public health relevance; repaired; research study; response; sensor; skull base; tool; two-dimensional; visual feedback

DESCRIPTION (provided by applicant): The primary objective of this SBIR effort is to develop a novel ultrathin (1~2 mm in diameter) scanning fiber endoscope (SFE) with simultaneous 2D/3D surface imaging capability. The proposed 3D-SFE will be able to provide, for the first time, dense 3D XYZ surface data that is co-registered with its 2D RGB counterpart, making 3D imaging an inherent part of SFE imaging capability without requiring users to perform any special manipulations or to take multiple images. The novel 3D imaging capability would greatly enhance the functionality of the existing SFE and enable it to perform, with its miniature probe size of 1~2 mm in diameter, a broad range of minimally invasive surgery procedures that were previously impossible to do. Unique features of the proposed novel 3D-SFE are: 7 High resolution full color 2D video image; 7 Unprecedented 3D imaging capability, with simultaneous and co-registered 2D and 3D image acquisition, possibly at video rate; 7 Single fiber scanner to generate stereo 3D images. 7 Dynamically adjustable field of view and image resolution; 7 Miniature size of the endoscope (~1 mm in diameter); 7 Extreme flexibility; and 7 Powerful 2D/3D image processing capability for minimally invasive surgeries. Xigen LLC proposes this comprehensive SBIR project, based on our strong collaborations and partnership with leading researchers/clinicians in multiple universities and hospitals. The Xigen team has long history and proven experience of attacking significant yet difficult 3D imaging problems in biomedical applications. Working closely with the research and clinical teams at the University of Washington who have developed multiple versions of working 2D scanning fiber endoscopes, we will develop full scale design, algorithms, hardware, software, and packaging for the 3D-SFE system, making it an integrated endoscopic image-guided system for minimally invasive surgeries that can access many sites that is currently impossible for existing endoscopes to do due to its ultra-thin diameter. This SBIR support will support thorough optical design, opto-electro-mechanical engineering development, 3D algorithmic development, and extensive tests. In Phase 1, the feasibility of the novel 3D-SFE will be thoroughly investigated. In Phase 2, working closely with clinical experts on our team, we will develop two fully functional 3D-SFE systems. We have streamlined our clinical study plan and focused on using 3D surface imaging capability for minimally invasive surgeries, such as otolaryngology surgeries (access sinus, middle ear, inner ear and skull based surgeries), and eye surgeries and drug placement on optic nerves. Proprietary Information of XIGEN LLC. 0 NIH SBIR PAR-09-220

描述（由申请人提供）：SBIR工作的主要目标是开发一种具有同时2D/3D表面成像能力的新型双通道（直径1~2 mm）扫描光纤内窥镜（SFE）。所提出的3D-SFE将能够首次提供与其2D RGB对应物共配准的密集3D XYZ表面数据，使3D成像成为SFE成像能力的固有部分，而无需用户执行任何特殊操作或拍摄多个图像。新的3D成像能力将大大增强现有SFE的功能，并使其能够使用直径为1~2 mm的微型探头执行以前不可能完成的广泛的微创手术程序。 所提出的新型3D-SFE的独特特征是：7高分辨率全色2D视频图像; 7前所未有的3D成像能力，具有同时和共配准的2D和3D图像采集，可能以视频速率; 7单光纤扫描仪生成立体3D图像。 7动态可调视野和图像分辨率; 7微型内窥镜（直径约1 mm）; 7极高的灵活性; 7强大的2D/3D图像处理能力，适用于微创手术。 Xigen LLC提出了这个全面的SBIR项目，基于我们与多所大学和医院的领先研究人员/临床医生的强大合作和伙伴关系。Xigen团队在解决生物医学应用中重要而困难的3D成像问题方面拥有悠久的历史和成熟的经验。与华盛顿大学的研究和临床团队密切合作，他们已经开发了多个版本的2D扫描光纤内窥镜，我们将为3D-SFE系统开发全尺寸设计、算法、硬件、软件和包装，使其成为集成的内窥镜图像-用于微创手术的引导系统，可以进入许多部位，这是目前现有内窥镜由于其超薄直径而不可能做到的。 SBIR支持将支持全面的光学设计、光电机械工程开发、3D算法开发和广泛的测试。在第一阶段，将彻底研究新型3D-SFE的可行性。在第二阶段，我们将与我们团队的临床专家密切合作，开发两个功能齐全的3D-SFE系统。我们简化了临床研究计划，并专注于将3D表面成像功能用于微创手术，例如耳鼻喉科手术（鼻窦、中耳、内耳和颅骨手术），以及眼科手术和视神经药物放置。XIGEN LLC的专有信息。0 NIH SBIR PAR-09-220