PIPER PROSTATE IMPLANT PLANNING ENGINE FOR RADIOTHERAPY

前列腺癌的粒子植入近距离放射治疗已被计划 在1995年后的10年中增长18倍，成为首选 2005年的治疗选择。实现一致高水平的主要障碍 在这一过程中标准和成本效益高的护理是缺乏健壮的 并优化治疗计划和实时剂量学指导。这个 这个拟议项目的具体目标和长期目标是 自主治疗计划和介入治疗指导， 分别进行了分析。核心技术包括遗传算法引擎 为每个患者设计最佳的种子植入物，一个决定- 理论导向剂，确保临床目标和 在10(2)秒的时间尺度内彻底探索了权衡取舍，并且 敏感度分析模块，模拟并降低可能性 实时手术偏离优化计划的情况。成熟度 基于Web的计算技术使这些技术能够集成 智能模块，为沉浸式治疗创造协同效应 远程医疗和术中环境的优化。这个 将开发和整合拟议的规划和指导系统 在这些技术的平台上。该系统的目标是 消除多余且容易出错的步骤，以简化临床医生- 人机界面，并提供逐步前馈优化。 建议的商业应用： 目前的商业应用将集中在自主 基于Internet或Intranet的治疗计划和实时 前列腺种子的介入性术中治疗指导 植入。适用范围可能扩大到放射治疗。 总体规划基于远程医疗网络的系统。真正的- 时间介入治疗系统具有很强的潜力。 再狭窄和置入导管室。

Seed implantation brachytherapy for prostate cancer has been projected to grow by 18-fold in the ten years since 1995, to become the preferred treatment option in 2005. The major obstacle to achieving uniformly high standard and cost-effective care in this procedure is the lack of robust and optimized treatment planning and real-time dosimetric guidance. The specific aim and long term objective of this proposed project are autonomous treatment planning and interventional treatment guidance, respectively. The core technologies include a genetic algorithm engine which designs the optimal seed implant for each patient, a decision- theoretic steering agent which ensures that the clinical objectives and tradeoffs are thoroughly explored in 10(2) second time scale, and a sensitivity analysis module which simulates and reduces the likelihood of real-time surgical deviations from the optimized plan. The maturity of web-based computing technology has enabled integration of these intelligent modules to create a synergy for immersive treatment optimization in both telemedical and intra-operative settings. The proposed planning and guidance system will be developed and integrated on the platform of these technologies. The system is targeted to eliminate redundant and error-prone steps, to streamline the clinician- machine interface, and to provide stepwise feedforward optimization. PROPOSED COMMERCIAL APPLICATION: The immediate commercial application will focus on the autonomous Internet or intranet based treatment planning and the real-time interventional intra-operative treatment guidance for prostate seed implantation. The scope of application may extend to radiation treatment planning in general for the telemedical network-based system. The real- time interventional systems have strong potential in the treatment of restenosis and in the setting of cath-lab.