Sono-Contrast Induced Functional Imaging/Spectroscopy

声对比诱导功能成像/光谱

• 批准号: 7230953
• 负责人: Yan Yu
• 金额: $ 31.84万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-26 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7230953
• 关键词: Acoustics; Biological Neural Networks; Biopsy; Blood Vessels; Blood flow; Classification; Contrast Media; Correlation Studies; Data Analyses; Deposition; Detection; Diagnosis; Diffuse; Focused Ultrasound Therapy; Functional Imaging; Functional disorder; Goals; Hemoglobin; Hypoxia; Image; Inbred C3H Mice; Invasive; Left; Leg; Location; Malignant - descriptor; Malignant Neoplasms; Mammary Neoplasms; Measurement; Measures; Medical Surveillance; Methods; Modality; Mus; Optics; Patients; Phase; Principal Component Analysis; Radiation; Radiation therapy; Receiver Operating Characteristics; Sensitivity and Specificity; Spectrum Analysis; System; Techniques; Testing; Time; Tissues; Treatment outcome; angiogenesis; base; cancer diagnosis; improved; in vivo; innovation; malignant breast neoplasm; outcome forecast; predictive modeling; research clinical testing; response; simulation; tumor

DESCRIPTION (provided by applicant): An innovative method of in vivo imaging for detection and pathophysiological classification of relatively superficial malignancies is proposed. The technique, sono-contrast induced functional imaging and spectroscopy (SCIFIS), builds upon existing diffuse reflectance spectroscopy (DRS) in the near infrared region but uses standing wave focused ultrasound deposition as a contrast agent to improve the sensitivity and specificity of DRS. The overall goal is to develop a non-invasive, real-time modality for cancer diagnosis, prognosis and post-treatment surveillance. The basis of the proposed in vivo imaging method is that acoustic radiation force delivered by focused ultrasound forming a standing wave causes reversible compression of the vasculature and/or blood flow stasis, and thus temporal changes in hemoglobin concentration, which are registered in the dynamic (pre- and post-insonification) observation of near-infrared spectra. By intersecting the optical path and the acoustic path at an angle and subtracting measured spectra pre- and post-deposition of sono-contrast, signatures of vascular pathophysiology can be identified at the intersecting location. In the R21 phase, C3H mice inoculated with murine mammary tumors on the left legs will undergo in vivo SCIFIS measurement prior to immunohistochemical examination. Principal component analysis neural networks (PCANN) will be used in data analysis/correlation, leading to definitively tests of the underlying hypotheses via receiver operating characteristics analysis and statistical correlation of tumor detection and vascular distribution predictions. In the R33 phase, clinical evaluation of the SCIFIS technique will commence following system optimization by Monte Carlo simulation. Non-invasive, in vivo acquisition of SCIFIS spectra will be collected in patients undergoing biopsy for suspicion of breast cancers. The predictive model based on PCANN will be quantitatively compared with pathological tissue diagnoses. In addition, response to radiation treatment and outcome will be correlated with angiogenesis and/or tumor hypoxia findings in the sonocontrast spectra for those patients who are found to have malignant diagnoses and eventually receive radiotherapy.

描述（由申请人提供）：

项目成果

Clinical study of a noninvasive multimodal sono-contrast induced spectroscopy system for breast cancer diagnosis.

用于乳腺癌诊断的无创多模式声对比诱导光谱系统的临床研究。

• DOI: 10.1118/1.3689811
• 发表时间: 2012
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Yan,K;Yu,Y;Tinney,E;Baraldi,R;Liao,L
• 通讯作者: Liao,L

Acoustic radiation force and optical spectroscopy for assessing tumor vessel normalization during anti-angiogenic therapy.

声辐射力和光谱学用于评估抗血管生成治疗期间肿瘤血管正常化。

• DOI: 10.1109/iembs.2009.5333814
• 发表时间: 2009
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Yan,Kaiguo;Wachsberger,Phyllis;Yu,Yan
• 通讯作者: Yu,Yan

Investigation of acoustic radiation force for radio-protecting normal tissues during radiation therapy.

放射治疗期间正常组织辐射防护的声辐射力研究。

• DOI: 10.1109/iembs.2009.5335044
• 发表时间: 2009
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Yan,Kaiguo;Wachsberger,Phyllis;Yu,Yan
• 通讯作者: Yu,Yan