课题基金 / 基金详情

INDUCTION AND SUPPRESSION OF NEOANGIOGENESIS

INDUCTION AND SUPPRESSION OF NEOANGIOGENESIS
诱导和抑制新血管生成
批准号:
2647829
负责人:
JEFFREY A GREENSPAN
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-05-18 至 1998-11-17

项目摘要

项目成果

JEFFREY A GREENSPAN的其他基金

相似基金

相关文献

中文摘要
翻译
描述:(改编自申请人摘要)。这个项目将
英文摘要
DESCRIPTION: (Adapted from the Applicant's Abstract). This project will examine the ability of a recently described protein, Cyr61, to induce localized vascular neoangiogenesis and to develop assays with which to screen specific inhibitors of this activity. Neoangiogenesis plays a critical role in wound healing and also is necessary for tumor growth and metastasis. Thus, therapeutic inhibitors of Cyr61 could be marketable anti-cancer drugs. The specific aims of phase I are the following: (1) demonstration that this protein induces neoangiogenesis in vivo; (2) establishment of an in vitro assay based on this protein's anticipated ability to promote the migration of capillary progenitor cells that can be used to screen rapidly for candidate anti-neoangiogenesis drugs; (3) to identify mammalian cell lines deficient in this protein and to use them to demonstrate the ability of Cyr61 to promote the growth of tumor associated vasculature in vivo. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Enhanced Wound Healing for Diabetics
  • 批准号:
    6484343
  • 项目类别:
  • 资助金额:
    $46.94万
  • 财政年份:
    2002
  • 负责人:
    JEFFREY A GREENSPAN
  • 依托单位:
ANTI-ANGIOGENIC MIMETICS FOR CANCER THERAPY
  • 批准号:
    6287887
  • 项目类别:
  • 资助金额:
    $25.0万
  • 财政年份:
    2001
  • 负责人:
    JEFFREY A GREENSPAN
  • 依托单位:
Novel Anti-Angiogenic Drugs for Cancer Therapy
  • 批准号:
    6334134
  • 项目类别:
  • 资助金额:
    $29.86万
  • 财政年份:
    2001
  • 负责人:
    JEFFREY A GREENSPAN
  • 依托单位:
INDUCTION AND SUPPRESSION OF ANGIOGENESIS
  • 批准号:
    6376771
  • 项目类别:
  • 资助金额:
    $31.84万
  • 财政年份:
    1998
  • 负责人:
    JEFFREY A GREENSPAN
  • 依托单位:
海外基金