Enhanced Wound Healing for Diabetics

描述(由申请人提供)：伤口愈合受损和延迟是糖尿病患者的主要问题。此外，老龄化和糖尿病共同加剧了这一问题。这些观察引起了人们对药物促进愈合的兴趣，这些生长因子参与了身体的创伤修复过程？S。临床试验一直令人沮丧，在人类伤口修复方面只有轻微的改善。研究表明，修复受损个体的细胞可能无法对生长因子做出足够的反应。因此，这些个体的伤口愈合可能不会通过生长因子治疗而得到改善，但可能需要给予下游因子，这些下游因子通常是在细胞中诱导的，以响应参与愈合的生长因子，但在伤口愈合能力较差的人的细胞中不会诱导。在这项提案的第一阶段，将测试一种特定的因子，它被强烈地涉及到身体伤口愈合的关键成分，其表达通常是由生长因子诱导的，将测试其促进糖尿病小鼠伤口愈合的能力。如果成功，这种因子将在第二阶段被开发为临床伤口愈合剂，特别是对那些受损的人。 伤口愈合，如糖尿病患者。 拟议的商业应用：伤口治疗费用总计数十亿美元(仅压疮一项就接近100亿美元)。伤口愈合受损和延迟每年影响50多万人，是糖尿病患者的重大问题(美国有超过1500万糖尿病患者)。还有老年人。愈合受损/延迟对导致心脏病发作(死亡的主要原因)和截肢的缺血也有严重影响。

Description (provided by applicant): Impaired and delayed wound healing are significant problems in diabetics. Furthermore, aging and diabetes together further compound the problem. These observations have created interest in pharmacologic enhancement of healing with growth factors involved in the body?s wound repair process. Clinical trials have been discouraging, with only modest improvement in wound repair in humans. Studies indicate that cells in healing-impaired individuals may fail to respond adequately to growth factors. Thus, wound healing in such individuals may not be improved by growth factor treatment, but may require administration of downstream factors normally induced in cells in response to growth factors involved in healing, but not induced in cells of those with poor wound healing capability. In Phase I of this proposal, a particular factor that is strongly implicated as a critical component of wound healing in the body, and whose expression is normally induced by growth factors, will be tested for its ability to enhance wound healing in diabetic mice. If successful, this factor will be developed in Phase II as a clinical wound-healing agent, particularly for those with impaired wound healing, such as diabetics. PROPOSED COMMERCIAL APPLICATION: Wound treatment costs total billions of dollars (almost $10 billion for pressure ulcers alone). Impaired and delayed wound healing affect more than a half million individuals annually and are significant problems in diabetics (over 15 million diabetics are in the U.S.) and the elderly. Impaired/delayed healing also has severe impact on ischemia that leads to heart attacks (the leading cause of mortality) and limb amputations.