CRYSTALLIZATION OF THERAPEUTIC MATERIALS

治疗材料的结晶

• 批准号: 2644047
• 负责人: GLENN T HONG
• 金额: $ 10万
• 依托单位: APHIOS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1998-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2644047
• 关键词: antineoplastics; biomedical equipment development; bryostatin; conformation; crystallization; drug /agent; drug quality /standard; insulin; method development; paclitaxel; solvents

High quality, pure crystals are of great value for a variety of industrial and research applications. Crystallization is frequently used as a method of purification in the biotechnology and pharmaceutical industries. More highly ordered crystals will typically results in a more highly purified product. Larger crystals can also impart advantages in packaging and handling operations, and may have advantages for controlled release drug delivery media. The objective of the present proposal is to demonstrate that anti solvent crystallization using liquefied gases, compressed gases, or cortical fluids (which have properties intermediate to gases and liquids) is a generally useful technique for forming large, high purity crystals from therapeutic materials such as natural product anti-cancer agents and macromolecules such as insulin. In the anti solvent technique, the material of interest is first dissolved in a suitable organic solvent. The compressed/liquified gas, e.g., carbon dioxide, in which the compound of interest is poorly soluble, is then slowly added to bring about crystallization. The program may also be useful in obtaining large single crystals for X-ray structural analyses to determine molecular conformations. Proposed commercial applications: The proposed process can benefit the pharmaceutical and biotech industries by yielding improved purity of therapeutic products with less residual solvent contamination. The technique can be useful in obtaining a desired particle size in drug manufacture, and may also prove useful in terms of controlled release formulations such as microspheres.

高品质、纯净的晶体对各种工业应用具有重要价值。 和研究应用。结晶经常被用作一种方法 生物技术和制药工业中的净化。更 高度有序的晶体通常会导致更高纯度的 产品较大的晶体还可以在包装和 处理操作，并且可以具有用于控制释放药物的优点 传递介质。本提案的目的是证明 使用液化气体，压缩气体， 或皮质流体（其具有气体的中间性质， 液体）通常是用于形成大的、高纯度的 来自治疗材料的晶体，例如天然产物抗癌 药物和大分子如胰岛素。在反溶剂技术中， 首先将感兴趣的材料溶解在合适的有机溶剂中。 压缩/液化气体，例如，二氧化碳，其中化合物 感兴趣的是难溶的，然后缓慢加入， 晶化该程序也可能是有用的，在获得大的单 用于X射线结构分析以确定分子量的晶体 构象 拟议的商业应用： 所提出的工艺可以使制药和生物技术行业受益 通过提高治疗产品的纯度， 溶剂污染。该技术可用于获得所需的 颗粒大小在药物制造中，并且也可以证明在 控释制剂如微球。