AFRICAN AMERICAN NEONATE FACE MORPHOMETRY--ETHANOL/TERATOGEN RISK SCREENING

非裔美国新生儿面部形态学--乙醇/致畸风险筛查

• 批准号: 6097750
• 负责人: VERLE HEADINGS
• 金额: $ 16.86万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6097750
• 关键词: African American; alcoholism /alcohol abuse; biomarker; clinical research; diagnosis design /evaluation; disease /disorder proneness /risk; embryo /fetus toxicology; ethanol; face; fetal alcohol syndrome; gestational age; human subject; mass screening; morphology; newborn human (0-6 weeks); prognosis; teratogens

Minor dysmorphologies of the face in the neonate are well accepted indicators of increased risk for impaired functions in central nervous system or for major malformation. About one-fourth of neonates at Howard University Hospital have been exposed to potential teratogens. Some of these yield developmental delays and minor face dysmorphologies. Clinical decisions about the letter typically are subject to high ovservor variability. There is need for a sensitive and objective method by which to decide which neonates are at risk for developmental delays. The goals of this study are to establish quantitative norms for 23 selected morphometric landmarks on the faces of African American neonates, and to test for potential shifts in such lnadmarks in response to alcohol and other teratogens to which these infants were exposed. Face photographs will be obtained on 1500 - 1700 unselected neonates and prenatal medical and teratogen histories recorded through screening interviews of their mothers. Measurements of distances among selected pairs of the 23 landmarks on the photographs will be analyzed by triangles defined by sets of three landmarks. The X, Y coordinates of the vertex landmark of each triangle will be tested by an F statistic for clustering according to each of the teratogen unexposed and exposed classes of infants.

新生儿面部的轻微畸形是公认的 中枢神经系统功能受损风险增加的指标 系统或严重畸形。 大约四分之一的新生儿在 霍华德大学医院被曝有可能 致畸剂 其中一些会导致发育迟缓， 畸形 关于信件的临床决定通常是 受到高观测器可变性影响。 需要一个敏感和 一种客观的方法来确定哪些新生儿有风险， 发育迟缓 本研究的目的是建立 23个选定的形态测量标志的定量标准， 非洲裔美国新生儿的脸，并测试潜在的变化， 这些标志是对酒精和其他致畸剂的反应， 这些婴儿受到了辐射 面部照片将于 1500 - 1700名新生儿和产前医疗和致畸剂 通过对他们母亲的筛选访谈记录的历史。 测量23个地标中选定对之间的距离 将通过由多组 三个地标 的顶点地标的X，Y坐标 每个三角形将通过F统计量进行测试，以根据 未接触致畸剂和接触致畸剂的婴儿的每一个类别。