AFRICAN AMERICAN NEONATE FACE MORPHOMETRY--ETHANOL/TERATOGEN RISK SCREENING

新生儿面部的轻微畸形被广泛接受 中枢神经功能受损风险增加的指标 系统或严重畸形。大约四分之一的新生儿在 霍华德大学医院已经暴露出潜在的 致畸者。其中一些会导致发育延迟和次要面孔 畸形症。关于这封信的临床决定通常是 易受卵子变异性的影响。有必要建立一种敏感和 用来确定哪些新生儿有患糖尿病风险的客观方法 发育迟缓。这项研究的目标是建立 选定的23个形态测量地标的定量规范 非裔美国新生儿的脸，并测试潜在的变化 这种标志是对酒精和其他致畸物质的反应 这些婴儿都接触过。面部照片将在以下地址获取 1500-1700名未经选择的新生儿与产前医学和致畸因素 通过对他们母亲的筛选访谈记录的历史。 23个地标中选定的几对之间的距离测量 将通过由以下集合定义的三角形来分析照片 三个地标。的顶点地标的X，Y坐标 每个三角形都将通过F统计量进行测试，以便根据 每一种致畸原均为未暴露和暴露类婴儿。

Minor dysmorphologies of the face in the neonate are well accepted indicators of increased risk for impaired functions in central nervous system or for major malformation. About one-fourth of neonates at Howard University Hospital have been exposed to potential teratogens. Some of these yield developmental delays and minor face dysmorphologies. Clinical decisions about the letter typically are subject to high ovservor variability. There is need for a sensitive and objective method by which to decide which neonates are at risk for developmental delays. The goals of this study are to establish quantitative norms for 23 selected morphometric landmarks on the faces of African American neonates, and to test for potential shifts in such lnadmarks in response to alcohol and other teratogens to which these infants were exposed. Face photographs will be obtained on 1500 - 1700 unselected neonates and prenatal medical and teratogen histories recorded through screening interviews of their mothers. Measurements of distances among selected pairs of the 23 landmarks on the photographs will be analyzed by triangles defined by sets of three landmarks. The X, Y coordinates of the vertex landmark of each triangle will be tested by an F statistic for clustering according to each of the teratogen unexposed and exposed classes of infants.