Unleashing Putida: Biobased Methacrylates for a Sustainable Future

该项目将应用世界一流的生物技术，为甲基丙烯酸酯（MAE）提供世界上第一个生物基商业上可行的制造工艺，甲基丙烯酸酯是聚甲基丙烯酸甲酯（有机玻璃）的基石，在可持续性方面具有革命性的改善。三菱化学株式会社（MCC -Japan）、Lucite International（总部位于英国的子公司）和英国生物技术中小企业Ingenza Ltd的合作，为目前仅使用不可持续的原料和化学制造工艺生产的产品带来了颠覆性创新。作为占有全球每年370万吨（67亿美元）甲基丙烯酸酯市场三分之一份额的市场领导者，MCC和Lucite拥有无与伦比的市场潜力和需求知识，以及工艺放大和工程专业知识，为项目产出提供令人信服的市场路线和健全的商业计划。世纪挑战集团的企业愿景要求将生物基甲基丙烯酸酯迅速推向市场，从而根据公司的KAITEKI原则履行其可持续发展承诺，即降低对化石燃料原材料的依赖，减少水消耗和整体降低碳足迹。突破性的技术，包括基于荧光激活细胞分选（FACS）的筛选，将选择用于发酵生产过程的微生物分离物，满足产品耐受性、生产率、操作稳健性和原料转化效率的性能标准。该项目将提供优化的生产有机体和一个经过验证的、可扩展的生物制造工艺，以降低项目后发展到商业试点的风险，为世界上最重要和最通用的耐用聚合物之一的成本竞争力和可持续制造做准备。因此，该项目旨在提供一个世界领先的商业工业生物技术成功的例子。_PERSPEX_(r)是_PERSPEX_ International的注册商标。

This project will apply world-class biotechnology to deliver the world's first bio-based commercially viable manufacturing process for methacrylate ester (MAE), the building block of poly-methylmethacrylate (Perspex(r)) with a game-changing improvement in sustainability. The collaboration of Mitsubishi Chemical Corporation (MCC --Japan), Lucite International, its UK headquartered subsidiary and UK based biotechnology SME, Ingenza Ltd thereby brings disruptive innovation to a product, currently manufactured solely using unsustainable feedstocks and chemical manufacturing processes. As market leaders with a one-third share of the annual global 3.7 million tons ($6.7bn) methacrylates market, MCC and Lucite possess unrivalled knowledge of the market potential and needs, as well as process scale-up and engineering expertise to provide a compelling route to market and a sound business plan for the project outputs. MCC's corporate vision demands a rapid realisation of biobased methacrylates being brought to the market, thereby fulfilling its sustainability commitments according to the corporation's KAITEKI principles of lower dependence on fossil fuel raw materials, reduced water consumption and overall lower carbon footprint. Ground breaking technology, including fluorescence activated cell sorting (FACS) based screening will select isolates of the microbe used in this fermentation based manufacturing process, meeting required performance criteria of product tolerance, productivity, operational robustness and feedstock conversion efficiency.The project will deliver the optimised production organism and a validated, scalable bio-manufacturing process that de-risks post-project progression to commercial piloting, in preparation for cost-competitive, sustainable manufacturing of one of the world's most important and versatile durable polymers. The project thereby aims to deliver a world-leading example of commercial industrial biotechnology success._PERSPEX_(r) is a registered trademark of _Perspex_ International.