POLYVALENT VANCOMYCIN AND MEMBRANE RECOGNITION

多价万古霉素和膜识别

• 批准号: 6077838
• 负责人: STEVEN J. METALLO
• 金额: $ 3.67万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6077838
• 关键词: cell membrane; drug design /synthesis /production; drug receptors; drug resistance; receptor binding; vancomycin

A polyvalent binding strategy will be used to develop antibiotics that are active against vancomycin resistant bacteria. A combination of vancomycin binding and membrane insertion moieties will be used to increase the overall affinity of the polymer for bacterial cell walls. The membrane binding portion will be further developed into a general strategy for binding and antibiotic action by the synthesis of polyvalent forms of host defense peptides that show wide antibacterial activity. These molecules should retain their specificity for bacterial membranes while increasing their potency via the cooperative nature of the polyvalent binding. Systems will be analyzed using surface plasmon resonance and cell culture techniques.

多价结合策略将用于开发抗生素， 对万古霉素耐药菌有活性。 的组合 万古霉素结合和膜插入部分将用于 增加聚合物对细菌细胞壁的总体亲和力。 膜结合部分将进一步发展成通用的 结合和抗生素作用的合成策略 多价形式的宿主防御肽显示出广泛的抗菌性， 活动 这些分子应该保留它们对细菌的特异性， 膜，同时通过协同性质增加其效力， 多价结合。 系统将使用表面等离子体进行分析 共振和细胞培养技术。