RETROSPLENIAL CORTEX CONTRIBUTIONS TO SPATIAL NAVIGATION

描述（改编自申请人的摘要）：本提案寻求 以解决多个结构如何相互作用来介导主动导航。 学习和记忆重要资源位置的能力是 对每种动物的生存能力都至关重要 因此， 对于理解神经系统如何相互作用来调节 这种行为。 拟议的研究将评估皮质对 海马和边缘丘脑的空间信息处理。 过去 解剖、损伤和电生理数据表明， 大脑皮层可能对空间学习做出独特的贡献。 是 这里假设压后皮质对 视觉和自我运动信息在边缘结构中的整合 被认为与航海有关。 为了验证这一假设， 损伤和压后皮质的暂时失活将结合在一起 海马和丘脑的慢性单单位记录， 主动导航 行为探针试验将用于确定变化 在去除压后皮质后的行为策略中。 是 预测在没有压后皮质的情况下， 视觉和自我运动信息将在空间中减少 相关记录从丘脑和海马和行为数据将 反映了空间记忆中的行为策略的类似变化 性能

DESCRIPTION (Adapted from applicant's abstract): The present proposal seeks to address how multiple structures interact to mediate active navigation. The ability to learn and remember locations of important resources is absolutely critical for every animal's ability to survive. As such, it is of great importance to understand how neural systems interact to mediate this behavior. The proposed studies will evaluate cortical contributions to processing of spatial information in hippocampus and limbic thalamus. Past anatomical, lesion and electrophysiological data suggest the retrosplenial cortex may make unique contributions to spatial learning. It is hypothesized here that retrosplenial cortex importantly contributes to the integration of visual and self movement information in limbic structures thought to be involved in navigation. To test this hypothesis, permanent lesions and temporary inactivation of retrosplenial cortex will be combined with chronic single unit recording from hippocampus and thalamus during active navigation. Behavioral probe trials will be used to identify changes in behavioral strategies following removal of retrosplenial cortex. It is predicted that in the absence of retrosplenial cortex the integration of visual and self movement information will be diminished in spatial correlates recorded from thalamus and hippocampus and behavioral data will reflect similar changes in behavioral strategies underlying spatial memory performance.