NEURAL BASIS OF FORM PERCEPTION IN A MODEL VISUAL SYSTEM

模型视觉系统中形式感知的神经基础

• 批准号: 2890029
• 负责人: HOLLY R CAMPBELL
• 金额: $ 1.91万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-02 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2890029
• 关键词: Diptera; alternatives to animals in research; behavior test; behavioral /social science research tag; biological models; electrophysiology; form /pattern perception; morphology; neural information processing; neuroanatomy; neuropil; orientation; visual perception; visual stimulus

This proposal investigates the neural basis of orientation and form perception by a non-vertebrate model system, the dipteran Phaenicia sericata. The research will identify visual parameters pertinent to low-level form vision using behavioral tests. It will then employ these parameters as stimuli for testing the filter properties of identified neurons in a neuropil having neuroanatomical characteristics analogous to mammalian visual cortex. To understand mechanisms of visual perception, investigations at the single cell level must be performed against a background of detailed morphological analysis such that the structure of single neurons responding to specific visual stimuli can be related to the overall neuroanatomical context of the system. The dipteran compound eye and optic lobes offer an ideal substrate for such an investigation. The optic lobes' succession of retinotopically organized neuropils is functionally analogous to organization amongst mammalian visual regions, but contains orders of magnitude fewer neurons. In particular, the planned research will focus on the lobula, a neuropil supplied by the parvicellular element of this visual system and containing within it nerve cells that are structurally analogous to pyramidal and stellate neurons of mammalian cortex. The relative simplicity of this model system facilitates the identification of single computational units and allows detailed circuit analysis A further advantage of this simple system is that it reflects evolutionarily conserved principles of visual system design that cut across phylogenetic boundaries. The proposed will investigate: . the ability of a dipteran species to discriminate visual patterns and shapes containing orientation and texture information. . the cellular properties of neurons and circuits in the lobula that discriminate orientations and textures. . the anatomical organization of pyramidal-like and stellate-like neurons in the dipteran lobula.

该提案研究了方向和形式的神经基础 非脊椎动物模型系统双翅目菲尼西亚的感知 绢毛。该研究将确定相关的视觉参数 使用行为测试进行低级形式视觉。然后它将雇用 这些参数作为测试过滤器特性的刺激 确定神经元中具有神经解剖学特征的神经元 类似于哺乳动物视觉皮层的特征。要了解 视觉感知机制，单细胞研究 水平必须在详细的背景下进行 形态学分析，例如单个神经元的结构 对特定视觉刺激的反应可能与整体有关 系统的神经解剖学背景。双翅目复眼和 视叶为此类研究提供了理想的基础。这 视叶连续的视网膜组织神经纤维是 功能上类似于哺乳动物视觉的组织 区域，但包含的神经元数量要少几个数量级。在 特别是，计划的研究将集中在小叶， 由该视觉系统的小细胞元件提供的神经纤维 并在其中包含结构上的神经细胞 类似于哺乳动物皮层的锥体和星状神经元。这 该模型系统的相对简单性有利于 识别单个计算单元并允许详细 电路分析 这个简单系统的另一个优点是 它反映了视觉系统进化上保守的原则 跨越系统发育边界的设计。拟议的遗嘱 调查： 。双翅目物种的辨别能力 包含方向和纹理的视觉图案和形状 信息。 。神经元和电路的细胞特性 区分方向和纹理的小叶。 。这 锥体样和星状神经元的解剖组织 在双翅目小叶中。