ESTROGEN AND D-AMPHETAMINE IN WOMEN

本研究旨在探讨雌激素对正常健康经期女性情绪和行为的影响。一个目标是研究不同浓度的雌激素对情绪变化和行为的影响，首先是月经周期中自然发生的正常生理波动的结果，其次是单剂量透皮雌激素外源性给药的结果。第二个目标是研究雌激素和兴奋剂d-安非他明之间的相互作用。这种组合将在正常周期的过程中进行研究，并在外源性给予雌激素和安非他明后进行研究。据推测，雌激素会产生改善情绪的作用，而d-安非他明的作用在雌激素水平较高的情况下会更大。这些相互作用是预期的，因为雌激素和d-安非他明都增强了大脑中多巴胺能系统的活性。

The purpose of the proposed studies is to investigate the role of estrogen on mood and behavior in normal healthy menstruating women. One goal is to investigate the mood-altering and behavioral effects of varying concentrations of estrogen, first as a result of normal physiological fluctuations that occur naturally across the menstrual cycle, and second as a result of exogenous administration of single doses of transdermal estrogen. The second goal is to investigate interactions between estrogen and a stimulant drug, d- amphetamine. This combination will be studied both during the course of the normal cycle, and after exogenous administration of both estrogen and amphetamine. It is hypothesized that estrogen will produce mood-enhancing effects, and that the effects of d- amphetamine will be greater in the presence of higher levels of estrogen. These interactions are expected because both estrogen and d-amphetamine enhance activity of the dopaminergic system in the brain.