ESTROGEN AND D-AMPHETAMINE IN WOMEN

建议研究的目的是调查雌激素对正常健康月经妇女情绪和行为的作用。一个目标是调查不同浓度的雌激素对情绪和行为的影响，首先是由于整个月经周期自然发生的正常生理波动的结果，其次是由于外源性单剂量经皮雌激素注射的结果。第二个目标是研究雌激素和兴奋剂d-苯丙胺之间的相互作用。这种结合将在正常周期的过程中以及在外源性给予雌激素和苯丙胺之后进行研究。据推测，雌激素会产生改善情绪的作用，而当雌激素水平较高时，d-苯丙胺的作用会更大。这些相互作用是意料之中的，因为雌激素和d-苯丙胺都能增强大脑中多巴胺能系统的活动。

The purpose of the proposed studies is to investigate the role of estrogen on mood and behavior in normal healthy menstruating women. One goal is to investigate the mood-altering and behavioral effects of varying concentrations of estrogen, first as a result of normal physiological fluctuations that occur naturally across the menstrual cycle, and second as a result of exogenous administration of single doses of transdermal estrogen. The second goal is to investigate interactions between estrogen and a stimulant drug, d- amphetamine. This combination will be studied both during the course of the normal cycle, and after exogenous administration of both estrogen and amphetamine. It is hypothesized that estrogen will produce mood-enhancing effects, and that the effects of d- amphetamine will be greater in the presence of higher levels of estrogen. These interactions are expected because both estrogen and d-amphetamine enhance activity of the dopaminergic system in the brain.