ESTROGEN AND D-AMPHETAMINE IN WOMEN

女性的雌激素和 D-安非他明

• 批准号: 6185158
• 负责人: ANGELA J JUSTICE
• 金额: $ 2.79万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6185158
• 关键词: amphetamines; behavioral /social science research tag; clinical research; combination chemotherapy; dosage; drug interactions; emotions; estrogens; female; human subject; menstrual cycle; psychopharmacology; psychophysiology; transdermal drug delivery

The purpose of the proposed studies is to investigate the role of estrogen on mood and behavior in normal healthy menstruating women. One goal is to investigate the mood-altering and behavioral effects of varying concentrations of estrogen, first as a result of normal physiological fluctuations that occur naturally across the menstrual cycle, and second as a result of exogenous administration of single doses of transdermal estrogen. The second goal is to investigate interactions between estrogen and a stimulant drug, d- amphetamine. This combination will be studied both during the course of the normal cycle, and after exogenous administration of both estrogen and amphetamine. It is hypothesized that estrogen will produce mood-enhancing effects, and that the effects of d- amphetamine will be greater in the presence of higher levels of estrogen. These interactions are expected because both estrogen and d-amphetamine enhance activity of the dopaminergic system in the brain.

本研究的目的是探讨雌激素对正常健康女性的情绪和行为的作用。一个目标是研究不同浓度的雌激素对情绪改变和行为的影响，首先是月经周期中自然发生的正常生理波动的结果，其次是外源性单剂量经皮雌激素的结果。 第二个目标是研究雌激素和一种兴奋剂药物--d-安非他明之间的相互作用。将在正常周期过程中和外源性给予雌激素和安非他明后研究这种组合。 据推测，雌激素会产生情绪增强的效果，并认为d-安非他明的效果将在更高水平的雌激素的存在下更大。 这些相互作用是预期的，因为雌激素和d-安非他明都增强了大脑中多巴胺能系统的活性。