ATTENTION AND INHIBITION IN CHILD AND YOUNG ADULT ADHD

对儿童和青少年多动症的关注和抑制

• 批准号: 2861563
• 负责人: CYNTHIA L HUANG-POLLOCK
• 金额: $ 2.58万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2861563
• 关键词: adolescence (12-20); age difference; alpha adrenergic receptor; attention; attention deficit disorder; behavioral /social science research tag; behavioral genetics; clinical research; family genetics; genetic susceptibility; human genetic material tag; human subject; mental disorder diagnosis; middle childhood (6-11); neural inhibition; nucleic acid repetitive sequence; space perception; visual perception; young adult human (21-34)

Attention deficit hyperactivity disorder (ADHD) is a serious, common, and chronic behavioral syndrome characterized by impaired attention, impulsivity, and excessive motor activity. It is a common reason for service referrals and is a risk factor for multiple poor outcomes. The proposed study would examine attentional and related inhibitory processes in the primarily hyperactive/impulsive (ADD+H) and primarily inattentive (ADD-H) subtypes at two developmental periods. A secondary goal of the proposed study, intended to increase the breadth of research, is to explore genetic contributions involved in the etiology of the two ADHD subtypes. Children will be recruited from local schools and pediatric clinics. Young adults will be recruited from the Disabilities Resource Center located on the Michigan State University Campus and through newspaper ads/fliers distributed in local communities. ADHD and comorbid diagnoses will be based on parent/ teacher and self report (questionnaires and a structured interview) for children and adults, respectively, according to DSM-IV criteria. Participants will complete a computer-generated attentional orienting task to measure the automatic and effortful allocation of visual attention and related inhibitory processes. Check cell samples for genetic analysis will be collected. The proposed cognitive neuroscience and genetic approach to understanding ADHD has the potential to better identify the primary cognitive dysfunction in ADHD as well as inform an etiologic model of these dysfunctions, and thus improve nosology, leading to the eventual development of better remedial programs.

注意缺陷多动障碍（ADHD）是一种严重、常见、