ATTENTION AND INHIBITION IN CHILD AND YOUNG ADULT ADHD

对儿童和青少年多动症的关注和抑制

• 批准号: 2861563
• 负责人: CYNTHIA L HUANG-POLLOCK
• 金额: $ 2.58万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2861563
• 关键词: adolescence (12-20); age difference; alpha adrenergic receptor; attention; attention deficit disorder; behavioral /social science research tag; behavioral genetics; clinical research; family genetics; genetic susceptibility; human genetic material tag; human subject; mental disorder diagnosis; middle childhood (6-11); neural inhibition; nucleic acid repetitive sequence; space perception; visual perception; young adult human (21-34)

Attention deficit hyperactivity disorder (ADHD) is a serious, common, and chronic behavioral syndrome characterized by impaired attention, impulsivity, and excessive motor activity. It is a common reason for service referrals and is a risk factor for multiple poor outcomes. The proposed study would examine attentional and related inhibitory processes in the primarily hyperactive/impulsive (ADD+H) and primarily inattentive (ADD-H) subtypes at two developmental periods. A secondary goal of the proposed study, intended to increase the breadth of research, is to explore genetic contributions involved in the etiology of the two ADHD subtypes. Children will be recruited from local schools and pediatric clinics. Young adults will be recruited from the Disabilities Resource Center located on the Michigan State University Campus and through newspaper ads/fliers distributed in local communities. ADHD and comorbid diagnoses will be based on parent/ teacher and self report (questionnaires and a structured interview) for children and adults, respectively, according to DSM-IV criteria. Participants will complete a computer-generated attentional orienting task to measure the automatic and effortful allocation of visual attention and related inhibitory processes. Check cell samples for genetic analysis will be collected. The proposed cognitive neuroscience and genetic approach to understanding ADHD has the potential to better identify the primary cognitive dysfunction in ADHD as well as inform an etiologic model of these dysfunctions, and thus improve nosology, leading to the eventual development of better remedial programs.

注意力缺陷多动障碍（ADHD）是一种严重的，常见的， 以及以注意力受损为特征的慢性行为综合征， 冲动和过度运动 这是一个常见的原因， 服务转介，是多种不良结果的风险因素。 的 拟议的研究将检查注意力和相关的抑制 主要是多动/冲动（ADD+H）的过程， 两个发育时期的注意力不集中（ADD-H）亚型。 次级 拟议研究的目标，旨在扩大 研究，是为了探索病因学中涉及的遗传因素 两种ADHD亚型的区别 儿童将从当地学校招募 和儿科诊所。 年轻的成年人将从 位于密歇根州立大学的残疾人资源中心 校园和通过报纸广告/传单分发在当地 社区. ADHD和共病诊断将基于父母/ 教师和自我报告（问卷调查和结构化访谈）， 儿童和成人，分别根据DSM-IV标准。 参与者将完成一个计算机生成的注意力定向 任务，以衡量自动和努力分配的视觉 注意力和相关的抑制过程。检查细胞样本 将进行遗传分析。 提出的认知神经科学 和遗传学的方法来理解多动症有可能更好地 识别ADHD中的主要认知功能障碍，并告知 这些功能障碍的病因模型，从而改善疾病分类学， 从而最终发展出更好的补救方案。