ATTENTION AND INHIBITION IN CHILD AND YOUNG ADULT ADHD

对儿童和青少年多动症的关注和抑制

• 批准号: 6391694
• 负责人: CYNTHIA L HUANG-POLLOCK
• 金额: $ 1.43万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6391694
• 关键词: adolescence (12-20); age difference; alpha adrenergic receptor; attention; attention deficit disorder; behavioral /social science research tag; behavioral genetics; clinical research; family genetics; genetic susceptibility; human genetic material tag; human subject; mental disorder diagnosis; middle childhood (6-11); neural inhibition; nucleic acid repetitive sequence; space perception; visual perception; young adult human (21-34)

Attention deficit hyperactivity disorder (ADHD) is a serious, common, and chronic behavioral syndrome characterized by impaired attention, impulsivity, and excessive motor activity. It is a common reason for service referrals and is a risk factor for multiple poor outcomes. The proposed study would examine attentional and related inhibitory processes in the primarily hyperactive/impulsive (ADD+H) and primarily inattentive (ADD-H) subtypes at two developmental periods. A secondary goal of the proposed study, intended to increase the breadth of research, is to explore genetic contributions involved in the etiology of the two ADHD subtypes. Children will be recruited from local schools and pediatric clinics. Young adults will be recruited from the Disabilities Resource Center located on the Michigan State University Campus and through newspaper ads/fliers distributed in local communities. ADHD and comorbid diagnoses will be based on parent/ teacher and self report (questionnaires and a structured interview) for children and adults, respectively, according to DSM-IV criteria. Participants will complete a computer-generated attentional orienting task to measure the automatic and effortful allocation of visual attention and related inhibitory processes. Check cell samples for genetic analysis will be collected. The proposed cognitive neuroscience and genetic approach to understanding ADHD has the potential to better identify the primary cognitive dysfunction in ADHD as well as inform an etiologic model of these dysfunctions, and thus improve nosology, leading to the eventual development of better remedial programs.

注意力缺陷多动障碍(ADHD)是一种严重、常见、 以及以注意力受损为特征的慢性行为综合症， 冲动和过度的运动活动。这是一个常见的原因 服务转介，是导致多个不良结果的风险因素。这个 拟议的研究将检查注意和相关的抑制。 主要是过度活跃/冲动(ADD+H)和主要 两个发育期的注意力不集中(Add-H)亚型。次要的 拟议研究的目标，意在增加 研究，是为了探索涉及病因学的基因贡献 两个ADHD亚型中的一个。孩子们将从当地学校招募 和儿科诊所。年轻的成年人将从 位于密歇根州立大学的残疾人资源中心 校园和通过在当地分发的报纸广告/传单 社区。ADHD和合并症的诊断将基于父母/ 教师和自我报告(问卷调查和结构化访谈) 儿童和成人分别根据DSM-IV标准。 参与者将完成计算机生成的注意力定向 测量视觉的自动和费力分配的任务 注意力和相关的抑制过程。检查细胞样本 基因分析将会被收集。提出的认知神经科学 用遗传学的方法了解ADHD有可能更好地 识别ADHD的主要认知功能障碍，并告知 这些功能障碍的病因学模型，从而改善病因学， 从而最终开发出更好的补救方案。