Developing treatments to turn back the 'cellular clock'

开发逆转“细胞时钟”的治疗方法

• 批准号: 93874
• 金额: $ 30.66万
• 依托单位: SENISCA
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=93874
• 关键词: Developing; treatments; turn; back; cellular

Ageing is a universal phenomenon and the primary risk factor for most common, chronic human diseases. Our company, SENISCA, is a spin-out from the University of Exeter, initially focussing on developing molecules suitable for treatment of skin ageing, followed by a wider vision to deliver innovative, effective pharmaceutical treatments for age-related diseases.Ageing occurs at the cell and tissue level because of failure of a few basic health maintenance mechanisms. The research leading to SENISCA's patent-protected innovation has identified a novel molecular mechanism of ageing that can be manipulated for cellular rejuvenation.SENISCA's existing data, showing that rejuvenation of senescent cells is possible, gives rise to the possibility of developing treatments for any age-related disease or condition with a senescence component. This project will focus on identifying combinations of naturally occurring or FDA-approved compounds with anti-ageing properties and obtaining primary safety and toxicity data in preparation for out-licensing to the skin ageing market.

衰老是一种普遍现象，也是最常见的人类慢性疾病的主要危险因素。我们的公司，SENISCA，是从埃克塞特大学分拆出来的，最初专注于开发适合治疗皮肤老化的分子，其次是更广阔的视野，为与年龄有关的疾病提供创新，有效的药物治疗。衰老发生在细胞和组织水平，因为一些基本的健康维持机制的失败。SENISCA专利保护创新的研究已经确定了一种新的衰老分子机制，可以通过操纵来实现细胞再生。SENISCA的现有数据显示，衰老细胞的再生是可能的，这为开发任何与年龄相关的疾病或带有衰老成分的病症的治疗方法提供了可能性。该项目将侧重于识别具有抗衰老特性的天然化合物或fda批准的化合物的组合，并获得主要的安全性和毒性数据，为皮肤老化市场的外许可做准备。