Identifying mechanisms and novel treatments of bone pain - closing the gap to the clinic. BonePainIII
确定骨痛的机制和新疗法——缩小与临床的差距。
基本信息
- 批准号:EP/Y036956/1
- 负责人:
- 金额:$ 33.22万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Musculoskeletal conditions are the most common cause of severe long term pain in the EU and lead to significant healthcare and social support costs. The prevalence increases with ageing, and as the lifespan of individuals is increasing and skeletal health is decreasing due to lifestyle factors such as obesity and lack of physical activity, the burden of bone pain on individuals and society is expected to further increase in the coming decades. Bone pain is notoriously difficult to treat with the available analgesics and there is a huge need for mechanism-based treatments. Therefore, it is pertinent to train highly skilled researchers to promote frontline research, innovation and education within bone pain. In BonePainIII we bring together 3 industrial beneficiaries, 4 academic beneficiaries, two industrial partners and three academic partners in a highly interdisciplinary and intersectoral network encompassing bioengineering, neuroscience, pharmacology, drug discovery and clinical medicine. BonePainIII will train a new generation of 10 creative, entrepreneurial and innovative early stages researchers (ESR), who in a doctoral programme will achieve research specific and transferable competences. The transferable skills program consists of workshops and courses covering essentials skills for a successful career in academic or non-academic sectors and includes entrepreneurship, knowledge transfer, open science, coding and artificial intelligence, communication, self-marketing, outreach, intellectual property rights, and environmental practices. A strong participation of the non-academic sector committed to hosting ESRs and to train through secondments and workshops ensures that the ESRs will be exposed to both academia and industry, and a gender balanced supervisor group will counteract gender-related barriers.Two major obstacles hamper drug discovery in bone pain: 1) the lack of understanding of the underlying molecular and cellular mechanisms of bone pain, and 2) a translational gap to the clinic. In BonePainIII, we will address these challenges through four integrated and ambitious, yet achievable research work packages.
肌肉骨骼疾病是欧盟长期严重疼痛的最常见原因,并导致巨额医疗和社会支持成本。骨痛的患病率随着年龄的增长而增加,随着个人寿命的延长,以及肥胖和缺乏体力活动等生活方式因素造成的骨骼健康下降,预计未来几十年个人和社会的骨痛负担将进一步增加。众所周知,骨痛很难用现有的止痛药来治疗,因此非常需要基于机制的治疗。因此,培养高技能的研究人员,促进骨痛领域的一线研究、创新和教育是有意义的。在BonePainIII中,我们将3名行业受益者、4名学术界受益者、2名行业合作伙伴和3名学术合作伙伴聚集在一个高度跨学科和跨部门的网络中,这个网络涵盖了生物工程、神经科学、药理学、药物发现和临床医学。BonePainIII将培训新一代10名创造性、创业性和创新性的早期研究人员(ESR),他们将在博士课程中获得特定研究和可转移的能力。可转让技能计划包括研讨会和课程,涵盖在学术或非学术部门成功职业生涯的基本技能,包括创业、知识转让、开放科学、编码和人工智能、通信、自我营销、外联、知识产权和环境实践。致力于托管ESRS并通过借调和研讨会进行培训的非学术部门的大力参与确保ESRS将与学术界和业界接触,性别平衡的主管小组将抵消与性别相关的障碍。阻碍骨痛药物发现的两大障碍:1)缺乏对骨痛的潜在分子和细胞机制的了解,2)与临床的翻译差距。在BonePainIII中,我们将通过四个综合的、雄心勃勃的、但可实现的研究工作方案来应对这些挑战。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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10.1016/s0016-5085(22)60790-x - 发表时间:
2022-05-01 - 期刊:
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Katie Barker;James Higham;Luke Pattison;Toni Taylor;Iain Chessell;Fraser Welsh;Ewan St. John Smith;David Bulmer - 通讯作者:
David Bulmer
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