FHS--MOLECULAR GENETICS AND GENETIC EPIDEMIOLOGY-CC

FHS--分子遗传学和遗传流行病学-CC

• 批准号: 6043906
• 负责人: Michael A. Province
• 金额: $ 50.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6043906
• 关键词: biomedical facility; cardiovascular disorder epidemiology; clinical research; cooperative study; coronary disorder; data collection methodology /evaluation; disease /disorder proneness /risk; family genetics; gene environment interaction; genetic models; human data; human population genetics; statistics /biometry

DESCRIPTION (Adapted from the applicants' abstract) FHS: Molecular Genetics and Genetic Epidemiology is submitted collaboratively by seven research groups including four clinical sites (University of North Carolina; Boston University; University of Minnesota; and University of Utah), a molecular biology laboratory (University of Utah), a coordinating center (Washington University, St. Louis, MO), a chemistry laboratory (University of Minnesota). The proposed study will perform state-of-the-art molecular genetic and genetic epidemiology studies using the extensive data on family and medical histories, risk factors, life style, blood specimens and banked DNA, previously collected by the Family Heart Study (FHS). The purpose is to identify and characterize genes of coronary heart disease (CHD) and atherosclerosis, familial environmental factors and behavioral characteristics, and to advance our understanding of how they interact with one another in the development of clinical outcomes.

描述（改编自申请人的摘要）FHS：分子遗传学 和遗传流行病学由七项研究合作提交 包括四个临床中心的小组（北卡罗来纳大学；波士顿 大学;明尼苏达大学；和犹他大学），分子 生物实验室（犹他大学）、协调中心（华盛顿 密苏里州圣路易斯大学），一个化学实验室（密苏里州圣路易斯大学） 明尼苏达州）。 拟议的研究将进行最先进的分子 利用广泛的家庭数据进行遗传和遗传流行病学研究 病史、危险因素、生活方式、血液样本和储存 DNA，之前由家庭心脏研究 (FHS) 收集。 目的是 识别和表征冠心病 (CHD) 基因 动脉粥样硬化、家族环境因素和行为 特征，并加深我们对它们如何相互作用的理解 临床结果的发展中彼此相互影响。

项目成果

Association of potato consumption with calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study.

食用马铃薯与冠状动脉钙化动脉粥样硬化斑块的关联：NHLBI 家庭心脏研究。

• DOI: 10.1016/j.numecd.2023.07.027
• 发表时间: 2023
• 期刊: Nutrition, metabolism, and cardiovascular diseases : NMCD
• 作者: Qavi,AhmedHassaan;Zhou,Guohai;Ward,RachelE;Carr,JohnJeffrey;Ellison,RCurtis;Arnett,DonnaK;Gaziano,JMichael;Djousse,Luc
• 通讯作者: Djousse,Luc

The impact of marker allele frequency misspecification in variance components quantitative trait locus analysis using sibship data.

使用同胞数据进行方差分量数量性状基因座分析中标记等位基因频率错误指定的影响。

• DOI: 10.1002/gepi.1370170713
• 发表时间: 1999
• 期刊: Genetic epidemiology.
• 作者: Borecki,IB;Province,MA
• 通讯作者: Province,MA

Evidence for three novel QTLs for adiposity on chromosome 2 with epistatic interactions: the NHLBI Family Heart Study.

• DOI: 10.1038/oby.2009.181
• 发表时间: 2009-12
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Feitosa MF;North KE;Myers RH;Pankow JS;Borecki IB
• 通讯作者: Borecki IB