Addressing the need for animal free testing of human acute toxicity

满足对人类急性毒性进行无动物测试的需求

• 批准号: 95482
• 金额: $ 30.13万
• 依托单位: XCELLR8 LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=95482
• 关键词: Addressing; need; animal; free; testing

XCellR8 Limited aims to offer the first completely animal-free, _in vitro_ test for human acute oral toxicity prediction, combining a strong scientific rationale with the ethical advantages of a non-animal approach.In response to the critical need in the cosmetics sector for scientifically advanced, non-animal tests for acute toxicity, XCellR8 developed a Proof of Principle test to show that this could be achieved. Companies in the sector find themselves stuck between two contradictory regulations. XCellR8's test indicates that there is a way to resolve this gap and allow cosmetic companies to test new ingredients, not only to remove the need to test on animals but also to provide a more accurate test for human toxicity than traditional rodent models by utilising human-derived components.An EC-funded feasibility study confirmed that in order to unlock the full market potential of the test, the predictive capacity and sector applicability should be expanded, significantly enhancing the commercial opportunity. Ingredient suppliers in a range of industries -- notably industrial chemicals, biocides and agrochemicals, and medical devices - expressed an interest in the test, citing similar contradictory regulations in their own sectors.This Project will enable XCellR8 to develop a new, improved test with features that enhance its predictive capacity, and to ensure its applicability to a wider range of sectors, solidifying the commercial proposition. This will aid in establishing a UK-based SME, XCellR8, as a world leading company for the provision of non-animal technologies for the testing of human safety.

XCellR8 Limited致力于提供第一个完全无动物的体外人体急性口服毒性预测测试，结合了强大的科学原理和非动物方法的伦理优势。为了响应化妆品行业对科学先进的非动物急性毒性测试的迫切需求，XCellR8开发了一个原理验证测试，以证明这是可以实现的。该行业的公司发现自己被困在两个相互矛盾的法规之间。XCellR8的测试表明，有一种方法可以解决这一差距，并允许化妆品公司测试新的成分，不仅消除了在动物身上进行测试的需要，而且还可以通过利用人类衍生成分来提供比传统啮齿动物模型更准确的人体毒性测试。一项由欧盟资助的可行性研究证实，为了释放测试的全部市场潜力，应扩大预测能力和部门适用性，大大增加商业机会。许多行业的供应商都表示对该测试感兴趣，尤其是工业化学品、杀虫剂和农用化学品以及医疗器械。他们指出，在自己的行业中存在类似的相互矛盾的规定。该项目将使XCellR8能够开发一种新的、改进的测试，其功能将增强其预测能力，并确保其适用于更广泛的行业，巩固商业主张。这将有助于建立一个总部位于英国的中小企业，XCellR8，作为一个世界领先的公司，提供非动物技术，用于测试人类安全。