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MECHANISM OF SPINDLE ASSEMBLY AND CHROMOSOME SEGREGATION

MECHANISM OF SPINDLE ASSEMBLY AND CHROMOSOME SEGREGATION
纺锤体组装和染色体分离机制
批准号：
2881582
负责人：
Claire E Walczak
金额：
$22.25万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-08-01 至 2004-07-31
来源：
https://reporter.nih.gov/project-details/2881582
关键词：
Xenopus affinity chromatography animal tissue centromere chromosome movement immunofluorescence technique kinesin microtubule associated protein mitotic spindle apparatus protein biosynthesis protein protein interaction yeast two hybrid system

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DESCRIPTION: Aim 1 is to further define how XKCM1 destabilizes microtubules by a series of domain studies. A second series of studies will be focused on establishing evolutionary conservation of the microtubule destabilizing activity of other KinI family members. Aim 2 is to identify and characterize proteins that interact with XKCM1. Here the applicant is particularly interested in identifying potential kinetochore components involved in association of XKCM1 with chromosomes. Aim 3 is to investigate the mechanism of chromosome segregation in Xenopus extracts. Aim 4 is to use reagents, developed in previous studies, to disrupt XKCMP1 function in vivo. Aim 5 is to assess chromosome movement in cells where XKCMP1 function has been manipulated as in the previous aim.
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