EPIDEMIOLOGY OF MARINE FATTY ACIDS AND PREECLAMPSIA

海洋脂肪酸与先兆子痫的流行病学

• 批准号: 2889149
• 负责人: MICHELLE A. WILLIAMS
• 金额: $ 27.74万
• 依托单位: SWEDISH MEDICAL CENTER, FIRST HILL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2889149
• 关键词: alcoholic beverage consumption; antioxidants; biomarker; blood chemistry; body physical activity; clinical research; dietary constituent; disease /disorder proneness /risk; eicosanoids; epidemiology; fatty acid biosynthesis; human pregnant subject; interview; marine animal oil; nutrition related tag; peroxidation; preeclampsia; pregnancy toxemia /hypertension; unsaturated fatty acids; urinalysis; women's health

DESCRIPTION: (Adapted from Investigator's Abstract) Preeclampsia, the third leading cause of maternal mortality in the United States, is an important cause of preterm delivery, fetal growth retardation, and perinatal mortality. Uteroplacental hypoperfusion is thought to be the primary defect in preeclampsia. Endothelial cell damage is also important in the pathogenesis of preeclampsia. Previous investigators have focused on the cause of these vascular insults. Findings from several disciplines indicate that preeclampsia is associated with excessive lipid peroxidation, oxidant-antioxidant imbalance, as well as an imbalance in n-3 and n-6 polyunsaturated fatty acids, and in thrombooxane and prostacyclin synthesis. Presently it is unknown whether these features precede preeclampsia or are secondary to the disease process. The authors propose to conduct a prospective cohort study of pregnant nulliparous women. The overall aim of the proposed research is to evaluate whether, and to what extent, maternal intake of dietary marine fatty acids and antioxidant vitamins are associated with risk of preeclampsia. The authors will collect maternal blood and urine specimens from a cohort of 1500 women during the first trimester of pregnancy. At the same time, information regarding medical and behavioral characteristics will be collected by interview. Medical records will be reviewed in order to collect information regarding pregnancy outcome. Blood and urine specimens will be processed and stored at -70C until analysis. Maternal intake of marine fatty acids and antioxidant vitamins will be assessed using biochemical and dietary methods. Eicosanoids and indicators of lipid peroxidation will also be evaluated. Using a nested case-cohort sampling design, the authors will identify 90 women with preeclampsia and an equal number of women with gestational hypertension. One hundred and fifty women randomly selected from the entire study cohort (N- 1500) will serve as a single reference group for all individuals sampled. Statistical analyses will focus on determining: (1) the extent to which lipid peroxidation and eicosanoid synthesis in the first trimester are associated with subsequent risk of preeclampsia and gestational hypertension, respectively; and (2) whether these metabolic factors are associated with maternal diet. The investigators state that clinical applications of study findings may result in early identification of women at risk of preeclampsia and an effective intervention.

描述：（改编自研究者摘要）先兆子痫， 美国产妇死亡的第三大原因是 早产、胎儿生长迟缓和 围产期死亡率 子宫胎盘灌注不足被认为是 先兆子痫的主要缺陷 内皮细胞损伤也是 在先兆子痫的发病机制中很重要。 以前的研究者 都集中在这些血管损伤的原因上 的结果 一些学科表明先兆子痫与 过度的脂质过氧化，氧化剂-抗氧化剂失衡，以及 n-3和n-6多不饱和脂肪酸不平衡， 血栓烷和前列环素的合成。 目前尚不清楚 无论这些特征是在先兆子痫之前还是继发于 疾病过程。 作者建议进行一项前瞻性队列研究， 对未经产孕妇的研究。 建议的总体目标 研究的目的是评估母亲是否以及在多大程度上摄入了 膳食海洋脂肪酸和抗氧化维生素与 先兆子痫的风险。 作者将收集母亲的血液和尿液 来自1500名女性的样本， 怀孕 与此同时，有关医疗和 将通过访谈收集行为特征。 医疗 将对记录进行审查，以收集以下信息 妊娠结局。 将处理血液和尿液样本， 在-70 ℃下储存直至分析。 母亲摄入海洋脂肪酸和 抗氧化维生素将使用生物化学和饮食 方法. 类花生酸和脂质过氧化的指标也将 评估。 使用巢式病例队列抽样设计，作者将 确定了90名先兆子痫妇女和同等数量的妇女， 妊娠期高血压 150名女性随机选择 整个研究队列（N- 1500）的样本将作为单一参考 对所有采样的个体进行分组。 统计分析将侧重于 确定：（1）脂质过氧化和类花生酸的程度 在怀孕的头三个月合成与随后的风险 先兆子痫和妊娠高血压，分别;和（2）是否 这些代谢因素与母亲的饮食有关。 的 研究人员指出，研究结果的临床应用可能 导致早期识别处于先兆子痫风险的妇女， 有效干预。