A Cohort Study of Preterm Delivery in Relation to Partner Abuse, Mood and Anxiety

早产与伴侣虐待、情绪和焦虑相关的队列研究

• 批准号: 8708920
• 负责人: MICHELLE A. WILLIAMS
• 金额: $ 54.68万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708920
• 关键词: Age; Anti-Inflammatory Agents; Anti-inflammatory; Anxiety; Anxiety Disorders; Behavioral; Biological; Biological Factors; Biological Markers; Biological Psychiatry; Blood Vessels; C-reactive protein; Child Abuse; Child Sexual Abuse; Clinical; Cohort Studies; Communities; Comorbidity; Complex; Congresses; Corticotropin-Releasing Hormone; Country; Education; Emotional; Environmental Exposure; Epidemiologic Studies; Exposure to; Failure; Family; Genetic; Goals; Health Status; Healthcare Systems; Immune; Individual; Infant; Infant Mortality; Inflammation; Institute of Medicine (U.S.); Institutes; Interdisciplinary Study; Interleukin-6; Intervention; Investments; Ischemia; Joints; Knowledge; Lead; Low income; Major Depressive Disorder; Maternal Exposure; Mediator of activation protein; Medical; Mental Depression; Mental Health; Metabolic; Mood Disorders; Moods; Mothers; Neurosecretory Systems; Newborn Infant; Outcome; Oxidative Stress; Partner Abuse; Pathway interactions; Perinatal; Perinatology; Personal Satisfaction; Physiological; Population; Post-Traumatic Stress Disorders; Pregnancy; Premature Birth; Prevalence; Prevention; Prevention strategy; Psychological Factors; Public Health; Recording of previous events; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Sexual abuse; Surgeon; Symptoms; Violence; Woman; abstracting; adverse outcome; base; clinical application; cohort; design; endothelial dysfunction; experience; girls; high risk; improved; innovation; intimate partner violence; member; minor depressive disorder; neuropsychological; physical abuse; premature; prospective; public health relevance; reproductive; social; symposium; treatment strategy; violence against women; young woman

DESCRIPTION (provided by investigator): Project Summary/Abstract (Description) Preterm delivery (PTD) continues to be one of the most significant unsolved problems of public health and perinatology. There is increasing evidence that PTD is a complex cluster of problems with a set of overlapping factors and influences. As recently summarized by the Institute of Medicine (IOM) the causes of PTD include individual-level behavioral and psychological factors, environmental exposures, medical conditions, biological factors, and genetics, many of which occur in combination. Members of the IOM expert panel also noted that persistent methodological limitations in previous studies, including treating PTD as a single entity and failure to recognize important common pathophysiological pathways that may lead to PTD (e.g., systematic inflammation, endothelial dysfunction, oxidative stress, and placental ischemia) have hindered discovery of potential treatment and prevention strategies. Previous studies have not rigorously evaluated the independent and joint effects of potent highly relevant social and neuropsychological risk factors of PTD in high risk populations. Increased efforts that integrate interdisciplinary research approaches are clearly needed to understand PTD from biological, clinical, and public health perspectives. The overarching objective of this study is to provide much-needed fundamental information concerning risk of PTD in relation to women's mental health status and exposure to violence before and during pregnancy. We will develop a prospective cohort of 6,000 Peruvian women. We will study the relation of maternal history of childhood sexual abuse, lifetime- and pregnancy-IPV with the prevalence of mood and anxiety disorders (e.g., major depression, minor depression, generalized anxiety and post-traumatic stress disorder [PTSD]). We will also study associations of PTD risk with mood disorder and anxiety disorder early in pregnancy. We will evaluate the extent to which risk of PTD is influenced by alternations in multiple biological markers of maternal neuroendocrine, vascular, and immune status. Finally, we will study the mediational effect of maternal mental health and physiological status in the relation between IPV and PTD.

描述(由研究人员提供)：项目摘要/摘要(描述)早产(PTD)仍然是公共卫生和围产期最重要的悬而未决的问题之一。越来越多的证据表明，PTD是一系列复杂的问题，具有一系列重叠的因素和影响。正如医学研究所(IOM)最近总结的那样，PTD的原因包括个人层面的行为和心理因素、环境暴露、医疗条件、生物因素和遗传因素，其中许多因素是共同发生的。国际移民组织专家小组成员还指出，先前研究中持续存在的方法学局限性，包括将PTD作为一个单一实体对待，以及未能认识到可能导致PTD的重要常见病理生理途径(例如，系统性炎症、内皮功能障碍、氧化应激和胎盘缺血)阻碍了潜在治疗和预防策略的发现。以前的研究没有严格地评估PTD在高危人群中的独立和联合作用，这些危险因素具有很强的高度相关性的社会和神经心理危险因素。为了从生物学、临床和公共卫生的角度理解PTD，显然需要更多的努力来整合跨学科的研究方法。这项研究的首要目标是提供急需的基本信息，说明与怀孕前和怀孕期间妇女的心理健康状况和暴力暴露有关的PTD风险。我们将建立一个由6000名秘鲁妇女组成的预期队列。我们将研究儿童期性虐待的母亲病史、终身和怀孕-IPV与情绪和焦虑症(例如，重度抑郁症、轻度抑郁症、广泛性焦虑和创伤后应激障碍[PTSD])的流行之间的关系。我们还将研究妊娠早期PTD风险与情绪障碍和焦虑障碍的关系。我们将评估母体神经内分泌、血管和免疫状态的多种生物标志物的变化对PTD风险的影响程度。最后，我们将研究母亲心理健康和生理状态在IPV与PTD关系中的中介作用。

项目成果

Childhood abuse and adult-onset asthma among Peruvian women.

• DOI: 10.1080/02770903.2017.1339243
• 发表时间: 2018-04
• 期刊: The Journal of asthma : official journal of the Association for the Care of Asthma
• 作者: Banerjee D;Gelaye B;Zhong QY;Sanchez SE;Williams MA
• 通讯作者: Williams MA

Concordance between self-reported pre-pregnancy body mass index (BMI) and BMI measured at the first prenatal study contact.

• DOI: 10.1186/s12884-016-0983-z
• 发表时间: 2016-07-26
• 期刊: BMC pregnancy and childbirth
• 影响因子: 3.1
• 作者: Natamba BK;Sanchez SE;Gelaye B;Williams MA
• 通讯作者: Williams MA

Validation of the Patient Health Questionnaire-9 (PHQ-9) for Detecting Depression Among Pregnant Women in Lima, Peru.

• DOI: 10.1007/s12144-020-00882-2
• 发表时间: 2022-06
• 期刊: CURRENT PSYCHOLOGY
• 影响因子: 2.8
• 作者: Smith, Meghan L;Sanchez, Sixto E;Rondon, Marta;Gradus, Jaimie L;Gelaye, Bizu
• 通讯作者: Gelaye, Bizu

The association between maternal cortisol and depression during pregnancy, a systematic review.

• DOI: 10.1007/s00737-017-0777-y
• 发表时间: 2018-03
• 期刊: Archives of women's mental health
• 作者: Orta OR;Gelaye B;Bain PA;Williams MA
• 通讯作者: Williams MA

Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women.

• DOI: 10.1158/1055-9965.epi-22-0069
• 发表时间: 2022-08-02
• 期刊: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
• 影响因子: 3.8
• 作者: Zavala, Valentina A.;Casavilca-Zambrano, Sandro;Navarro-Vasquez, Jeannie;Castaneda, Carlos A.;Valencia, Guillermo;Morante, Zaida;Calderon, Monica;Abugattas, Julio E.;Gomez, Henry;Fuentes, Hugo A.;Liendo-Picoaga, Ruddy;Cotrina, Jose M.;Monge, Claudia;Neciosup, Silvia P.;Huntsman, Scott;Hu, Donglei;Sanchez, Sixto E.;Williams, Michelle A.;Nunez-Marrero, Angel;Godoy, Lenin;Hechmer, Aaron;Olshen, Adam B.;Dutil, Julie;Ziv, Elad;Zabaleta, Jovanny;Gelaye, Bizu;Vasquez, Jule;Galvez-Nino, Marco;Enriquez-Vera, Daniel;Vidaurre, Tatiana;Fejerman, Laura
• 通讯作者: Fejerman, Laura