DNA printing on a synthetic polymer template

合成聚合物模板上的 DNA 打印

• 批准号: DP190100055
• 负责人: Prof Amanda Ellis
• 金额: $ 26.12万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-01 至 2023-04-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190100055
• 关键词: DNA; printing; synthetic; polymer; template

This project aims to design and study DNA printing to manufacture long strands of DNA using simple but elegant fundamental non-enzymatic chemical reactions. Gene therapy is one of the most rapidly growing therapies in modern medicine but it is prohibitively expensive for the average person. Current methods of artificial gene synthesis are complicated with commercial DNA synthesis only supplying short DNA strands. The project outcomes will lead to a stable template directing the chemical reactions for DNA printing. This new approach will make life-saving gene therapy cheaper and more widely available for future generations and provide economic, and social benefits to all Australians.

这个项目的目的是设计和研究DNA打印，利用简单而优雅的基本非酶化学反应来制造长链DNA。基因疗法是现代医学中发展最快的疗法之一，但对普通人来说，它的费用高得令人望而却步。目前的人工基因合成方法很复杂，商业DNA合成只提供短的DNA链。该项目的成果将导致一个稳定的模板，指导DNA打印的化学反应。这一新方法将使拯救生命的基因疗法更便宜，更广泛地为子孙后代提供，并为所有澳大利亚人提供经济和社会效益。