PARAMETRIC BLIND DECONVOLUTION OF MICROSCOPIC IMAGES
显微图像的参数盲解卷积
基本信息
- 批准号:2907740
- 负责人:
- 金额:$ 22.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-08-01 至 2002-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (From the Abstract) Computational optical sectioning microscopy
(COSM) is gaining acceptance as an alternative as well as a complement to
confocal scanning microscopes (CSM) and two-photo fluorescence excitation
microscopes (TPFEM). COSM algorithms remove out-of-focus light from wide-field
microscope images and can also improve the resolution in CSMs and TPFEMs. The
algorithms require knowledge of the process of image formation usually
represented by the point-spread function (PSF), the image of a point source of
light. In modern scanning microscopes, the measurement of computation of the
PSF is difficult at best. In these cases, it is necessary to estimate the PSF
and the specimen fluorescence distribution simultaneously from the image; an
approach called blind deconvolution (BD). We developed a method for blind
deconvolution in which the PSF is constrained to follow a mathematical model
that depends on a small number of unknown parameters. The parametric BD (PBD)
method determines these parameters together with the specimen function. We have
found encouraging results but the PBD is still computationally intensive.
The purpose of this research is to9 make this method practical for routine use
and to extend its application to CSMs and TOFEMS. The method will be optimized
and its capabilities and limitations thoroughly assessed to be able to provide
guidelines for its use. In addition, the method will be incorporated into a
deconvolution package that our group developed.
描述:(摘自摘要)计算光学切片显微镜
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSE-ANGEL CONCHELLO其他文献
JOSE-ANGEL CONCHELLO的其他文献
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{{ truncateString('JOSE-ANGEL CONCHELLO', 18)}}的其他基金
COMPUTATIONAL OPTICAL SECTIONING MICROSCOPY ALGORITHMS
计算光学切片显微镜算法
- 批准号:
2910317 - 财政年份:1997
- 资助金额:
$ 22.45万 - 项目类别:
Computational Optical Sectioning Microscopy Algorithms
计算光学切片显微镜算法
- 批准号:
6682927 - 财政年份:1997
- 资助金额:
$ 22.45万 - 项目类别:
COMPUTATIONAL OPTICAL SECTIONING MICROSCOPY ALGORITHMS
计算光学切片显微镜算法
- 批准号:
2701827 - 财政年份:1997
- 资助金额:
$ 22.45万 - 项目类别:
Computational Optical Sectioning Microscopy Algorithms
计算光学切片显微镜算法
- 批准号:
6796225 - 财政年份:1997
- 资助金额:
$ 22.45万 - 项目类别:
COMPUTATIONAL OPTICAL SECTIONING MICROSCOPY ALGORITHMS
计算光学切片显微镜算法
- 批准号:
2024260 - 财政年份:1997
- 资助金额:
$ 22.45万 - 项目类别:
Computational Optical Sectioning Microscopy Algorithms
计算光学切片显微镜算法
- 批准号:
6473523 - 财政年份:1997
- 资助金额:
$ 22.45万 - 项目类别:
PARAMETRIC BLIND DECONVOLUTION OF MICROSCOPIC IMAGES
显微图像的参数盲解卷积
- 批准号:
2749943 - 财政年份:1993
- 资助金额:
$ 22.45万 - 项目类别:
PARAMETRIC BLIND DECONVOLUTION OF MICROSCOPIC IMAGES
显微图像的参数盲解卷积
- 批准号:
6180213 - 财政年份:1993
- 资助金额:
$ 22.45万 - 项目类别: