NEURONAL CORRELATES OF HUMAN MEMORY

描述：(研究者摘要)：人类记忆的神经机制 利用一个独特的机会进行调查，开颅手术 手术的一部分，病人在局部麻醉下苏醒。 在这些操作的过程中，与记忆一起发生的神经活动 测量是由细胞外微电极记录在人的外侧 颞叶和内嗅皮层，以及海马体。多个方面或记忆 在这些记录期间进行评估，包括长期语义、近期 外显后分心、工作和内隐记忆与回忆 检索的识别模式。记忆的这些不同方面是 评估三种类型的口头材料，视觉呈现的名称 物体、词语和听觉词语。根据我们之前的观察，我们 期望识别与记忆的各个方面相关的神经元 外侧的颞叶皮质，以及更内侧的颞叶结构。 单个神经元将与记忆的特定方面相关，并且对于 记忆的相同方面，与特定类型的言语材料有关。每个人 每种语言材料的记忆方面都有不同的神经 在颞叶的系统。因此，这项研究将更清楚地定义 人类言语记忆的细分，并建立了一些变化 与它们一起发生的神经活动。

DESCRIPTION: (Investigator's Abstract): Neural mechanisms of human memory are investigated utilizing a unique opportunity, craniotomy where the patient is awake under local anesthesia for a portion of the operation. During the portion of these operation, neural activity occurring with memory measures is recorded by extracellular microelectrodes in human lateral temporal and entorhinal cortex, and hippocampus. Multiple aspects or memory are evaluated during those recordings, including long-term semantic, recent explicit post-distractional, working, and implicit memory and recall and recognition modes of retrieval. These various aspects of memory are assessed for three types of verbal material, visually presented names of objects and words and auditory words. based on our previous observation, we expect to identify neurons related to the various aspects of memory in lateral temporal cortex, as well as more medial temporal structures. Individual neurons will be related to a specific aspect of memory, and for the same aspect of memory, to a specific type of verbal material. Each aspect of memory for each type of verbal material has separate neural systems in temporal lobe. This study, then, will more clearly define the subdivisions of human verbal memory and establish some of the changes in neural activity occurring with them.